A three-month period in the lives of our heroes and villains is chronicled. Dr. Venture recruits college interns to help him complete a project for J.J. in time, but things go awry. Dean makes a life-changing decision after Triana rejects him, and Billy Quizboy acquires a new archenemy.

The Ventures travel into the jungles of Central America to find an invention that has developed a mind of its own.

While the Monarch and his wife attempt to destroy the Venture compound once and for all, the Monarch learns a startling secret about his past. Meanwhile, Twenty-One tries to create a new SPHINX... and inadvertently recruits the members of the old SPHINX.

A figure from Dr. Venture's past haunts him during his annual vacation to Spanikos.

OSI has a riot on their hands when the super-villains in their custody make a desperate bid to escape.

Dean pays a visit to the mystery woman in his life, while Hank and Dermott play a prank on Dr. Venture which leads him on a quest to find his mystery friend and rescue him.

When Rusty is apparently killed by the Monarch, Hatred sends the boys off to live with their godparents, and then turns to Twenty-One for help to infiltrate the Flying Cocoon and recover Rusty's body.