The body of a man is discovered on the Brooklyn Bridge, and the only evidence is a huge marriage proposal in lights. The CSI team works through the investigation as they learn to deal with a new medical examiner.

Three women who are dressed as Holly Golightly rob a jewelry store and injure other shoppers in the process. The CSI’s must work through the confusing investigation to hunt them down. Meanwhile Mac has to identify a mummified body discovered in an apartment building that was being torn down.

A young woman dies after she starts bleeding from the eyes, nose, and mouth while at a party aboard a subway train. Mac originally believes she is the victim of a biological attack. Later, it is revealed that Sheldon knew the victim. Across town, a wealthy playboy is found dead in an indoor lap pool in his penthouse suite. The investigation reveals that he was murdered and his last maid was fired two days earlier.

After a bartender is murdered The CSI team must prove that Hawkes did not commit the murder. That only becomes more difficult when the team is pulled off the investigation.

The CSI team has a problem after learning the family is deaf: now they have to find a new way to catch the killer. Meanwhile, more information is given on Lindsey's horrifying past and what led her to become a CSI.

Mac may have a difficult time solving the murder of a music mogul the sister cleverly uses a lie detector test to cover up the crime. Stella wonders if she has HIV due to an accident.

Can the team clear a tennis legend of murder? Also Mac believes that the continuing investigation into what happened with Clay Dobson is nothing but media pressure. Can friends and colleagues help save Mac Taylor’s career before it’s too late?

After Flack makes an enormous drug bust, and locks it up at CSI, the drug lords infiltrate the building at gunpoint to get them back. Now the team must resolve the hostage situations, all the while with Mac, Stella, and Hawkes trapped inside.