The body of a dead real estate agent is found in the walk-in closet of Mark's sister's new house. Mark and Steve have to work around Dora Sloan's annoying habits while investigating the murder.

The newly crowned boxing champion is found murdered shortly after the bout. Jack and Amanda investigate the deceased's former trainer, his opponent, and his opponent's manager to find a way through a web of lies and deceit.

When an unpopular actor on a hot new medical drama (being filmed at Community General) suddenly dies, Mark suspects everyone from the writer to other cast members.

The death of a popular musician raises suspicious questions. The musicians' pregnant wife, who claims to be carrying an alien's child, complicates matters.

Amanda's cousin falls to his death when his motorcycle suddenly veers off the road. Amanda leads the investigation when it's discovered her cousin was drugged immediately before the accident.

Dr. Sloan investigates a free health clinic after several homeless people turn up dead... with missing organs.

The daughter of one of Mark's friends writes a juicy tell-all expose of the most prominent public figures. Mark takes her in after a crazed stalker starts threatening her and her co-authors.

A figure skater hires her ex-coach to attack a rival skater. Dr. Sloan tries to prove her guilt.

His scheming advisor covers up the accidental death of the drug-addicted daughter of a U.S. Senator. Dr. Sloan and Amanda investigate.

Jesse is arrested and charged with murder after a doctor testifying against Jesse in a malpractice suit is poisoned. Mark convinces his old friend, Ben Matlock, to defend Jesse.

Amanda and Ben investigate the murder of Eric Spindler while Jesse continues to languish in jail.

When a musician is found murdered at a Country Music Awards ceremony, Dr. Sloan and company rush to find the culprit before the show ends and the crowd disappears.

A devious psychologist uses hypnotism to facilitate his criminal acts, including the murder of his wife.

A bungling comedian seeks revenge on his former partner when he's cheated out of millions.

Dr. Sloan is stalked by a mad bomber whom he helped incarcerate. Norman and Mark are the main dissenters in negotiations to sell the hospital to a corporate raider.

Mark investigates when a teenage girl is murdered after threatening to reveal her affair with her older lover, a newly appointed state Supreme Court Justice.

Community General is already under increased security, with a high-profile criminal hospitalized, when an important businesswoman is brought in. Mark suspects her security guard has deadly intentions.

Dr. Sloan investigates a plastic surgeon when an actress's death apparently results from an infection contracted during surgery.

The Sloans run into plenty of industry politics when they investigate the death of television network executive, Rachel Woodrall. Seamy revelations about Woodrall's college sorority lead to the killer.

A dead mime leads to an investigation of a crooked auto dealer. Randy Wolfe, a woman who's apparently an expert at everything, leads the investigation while continually annoying Steve.

Dr. Sloan investigates to find out who's behind the death of a driver in a speedway crash.

The hospital is the scene of a manhunt when a corpse comes to life and attacks Amanda, then leads Steve and the police on a chase throughout the entire building during which he kidnaps Jesse's girlfriend Steve. Mark learns the fugitive is on the run from NSA agents, who claim he's an international terrorist.

Newly retired detective Harry Trumble returns to the force when it appears 'The Clown Killer', a murderer Trumble chased for more than a decade, has emerged from obscurity to kill again. Mark is reluctant to help Harry investigate the Clown, in part due to a rift between the two, but also because Mark suspects Harry has something to do with the Clown's reappearance.

A serial murderer strikes Community General every hour on the hour, choosing victims who've been seriously injured but 'brought back to life'.

A comedy roast in Mark's honor is ruined by a double murder.

A fiendish med student sells prescription pads to a drug dealer and murders his partner when she becomes too needy. Mark plays Columbo to nail the murderer.

Mark matches wits with a beautiful jewel thief who's being framed for murder.

Mark investigates when a philandering chef is murdered during a televised charity cook-off.

A devious home security programmer plots to murder the children of everyone involved in the accidental death of his son.

Mark's office decorator is murdered.

Dr. Sloan tries to save Jesse and Amanda from a murderer who is out to kill them in order to obtain a multi-million dollar inheritance.

In Los Rios enroute to Los Angeles, Carol makes an urgent call to her father, Dr. Mark Sloan, pleading for help. Arriving in the small, seemingly pleasant mountain town, Mark investigates but the whole community denies knowing anything about his daughter and her husband.