Lucas, Nathan and Jake are auctioned off to the highest bidder in the annual "Boy Toy" charity auction and the night leads to surprising developments with old flames. Meanwhile, having missed out on the auction, Brooke ends up with Mouth and gives him the night of his life.

With the assistance of Peyton and Brooke, Lucas throws Nathan and Haley a wedding reception. Although Haley's parents support the marriage, Deb has a difficult time accepting it. Meanwhile, Dan's recent heart attack causes him to try and mend his relationships with Deb and Lucas.

The girls of Tree Hill have a slumber party, at which time secrets are revealed and bonds are made. Meanwhile, Nathan and Lucas road trip to Charlotte for a basketball game, and unknowingly to Lucas, they embark upon free HCM tests, a genetic heart condition that Dan maintains. Karen and Andy have a row.

Keith and Jules' wedding day, and the event has turned the town upside down. Brooke asks Lucas to take her to the wedding as his date, Nathan makes an important decision involving his marriage to Haley, and Jake and Peyton take a big step in their relationship. Meanwhile, Karen and Andy discover Jules' secret relationship with Dan.

Nathan asks Haley for a possible divorce. Lucas tells Dan that he saved his life. Peyton finds out something deep about Ellie. Dan tries to drop accusations at several people about the fire. He also tries to get Whitey replaced as Ravens coach.

When someone unleashes the students' time capsule upon Tree Hill High, Lucas and Mouth must confront a person from their past. Brooke has to deal with the revelation that secrets aren't the only things she exposed in the time capsule. Dan learns to forgive Keith. Haley is forced to reconcile the man Nathan was before with the man he has become, and Peyton's Breast Cancer Benefit Concert at Tric features performances by Haley, Jack's Mannequin and the return of Fall Out Boy.

Nathan deals with a player who is a rival both on and off the court. Meanwhile, Brooke and Mouth look to get even with Rachel. Dan has a run-in with Cooper; and Peyton comes to a major decision.