Since Samantha has no memories of the past, including her sexual experiences, she is faced with the decision of waiting this time for the right guy to come along, or to experiment.

Samantha is suspicious about Regina's action, which lead her to believe she is having an affair. But she's not alone. Todd is cheating on Chloe, who is none the wiser, with Samantha. Dena and Regina are contemplating opening up their own coffee shop.

Sam tries to make herself appear to be an environmentalist, so Owen might like her more. Andrea doesn't fare well when the basketball player, Tony Dane, is looking for a date.

Sam decides to give Todd a second chance by going out with him on another "first date," but Todd doesn't trust Winston Funk, believing he and Sam may continue the affair they were having before the accident. Meanwhile, Andrea appears on a reality TV series about celebrity weddings, along with her gay basketball star Tony Dane.