Terence is back and he calls in Tim Scam, Helga Von Gugen, Boogie Gus, and Myrna Beesbottom to create the 'League Aiming to Menace and Overthrow Spies', the LAMOS. Also Myrna creates triplet male androids Scyler, Tyler, and Wyler that can drain the girls' energy to destroy them and WOOHP. In the b-story, Clover and Mandy compete to be the best photogenic. Villains: Myrna Beesbottom (L.A.M.O.S).

During a cheer leading practice, Mandy breaks a nail and has to work as a TV reporter to kill time for her nail to grow back. Meanwhile, during a clean-up of Jerry's office, the spies discover a gadget that accidentally sends them twenty years into the future. While there, they soon uncover the horrifying truth that Mandy rules Beverly Hills and she plans to 'Mandify' everyone! Teaming up with their future self, the girls must stop her and stop it from ever happening. The spies arrive to Future WOOHP and return to present by the time machine. In the end, the spies put the recreate nails in Clover's school wardrobe. Mandy sneaks in and takes the recreate nails. She's got normal nails again and decides to quit from work of TV Reporter. In the b-story, Mandy is upset because what she will do with her broken nails. Villain: Mandy.

Note: This episode indicates that the timeline for season 4 occurs in 2005 because they say that when it's 2025, it's 20 years into the future.

Boogie Gus invents a gun ray that can not only make people look like from the '80s but also makes them younger! In the b-story, Jerry is having a date with his friend from the band. Villain: Boogie Gus (L.A.M.O.S.).

The girls uncover a secret conspiracy of parents brainwashing their children into becoming model teenagers. And things get a lot worse when Alex falls directly into the trap, leading Sam and Clover on a mission to save her! In the b-story, Jerry gives the girls a car called NPU 3000. Villain: The parents of the brainwashed children.

Alex is sent to Dorsal Academy in England after getting all Fs in her report card when it was inadvertently switched with Mandy's report card, only to find out that the principal plans to turns everyone into dolphins! After Sam and Clover have rescued Alex, it's revealed that Alex's grades were really As and Bs and the person who got all Fs was Mandy! In the b-story, Jerry moves to spies' house when the bugs attacked his house. Villain: Principal Sharminston.

A mime plans to turn everyone into silent mimes with his accordion after a failed performance in order to get revenge, another way to stop Alex from telling Sam & Clover's secrets! In the b-story, Sam and Clover are mad because Alex tells their secrets. Villain: Jazz Hands.

It's that magical time of year again – time to crown the new Miss Beverly Hills. Among this year’s hopeful contestants are Mandy and Clover. In order to get that extra winning edge, both Mandy and Clover unwittingly decide to get a special full-body makeover that promises to make their hair, smiles, eyes and even their attitudes bigger. But as they are getting their treatment, a shadowy figure sneaks into the spa and puts a microchip into Mandy’s machine. At first, Mandy is pleased with the results of her treatment which seems to have worked better than Clover's. She doesn't realize it at first, but as she gets larger and larger, she can't deny what's happening to her. As the spies start to investigate a rash of disappearances among Miss Beverly Hills contestants, they find out that Mandy, who has now grown nearly fifty feet tall, is behind the crimes! They also discover that along with becoming bigger physically, Mandy's meanness has also become magnified--and in an effort to win the competition, she decided to take out the other contestants. It's revealed the shadowy figure is Smalls! The spies save the contestants and Mandy attacks the spies. Smalls arrives and turns Clover into a giantess. As Clover and Mandy are fighting, Sam and Alex defeat Smalls and return Clover and Mandy to their normal size. In a b-story, Clover tries out an entire litany of ridiculous talents to find something she's good at so she can win the talent portion of the Miss Beverly Hills competition. Villain: Mandy (Diminutive Smalls).

Tim Scam sends Jerry his favorite chocolate containing Terence's DNA to turn him evil! It's up to spies to save the day. At the end of episode Helga Von Guggen, Tim Scam, and Myrna Beesbottom were arrested. In the b-story, Mandy and her cronies create the spy club. Villain: Terence Lewis (L.A.M.O.S.).

Jerry is invited to work for a spy film. But what he doesn't know is the director is Lumière in disguise and he plans to take revenge on all the other producers for refusing his film! In the b-story, while Jerry is absent, the spies must rule the WOOHP. Villain: Marco Lumière.

Following a humiliation in the lunchroom, Arnold is left depressed. That night, as they watch someone breaking into an armoured van, Arnold dressed as a superhero appears, and attempts to capture the man. The van seals, and drives off a cliff. Sam, Clover, and Alex save Arnold beforehand, and make him swear to keep their identities secret. Geraldine Husk appears after the spies leave, and gives Arnold a utility belt. The next day, Arnold's superhero alter ego has been reported saving people, but the device is secretly brainwashing Arnold to destroy the spies. In a b story, Alex finds a stray puppy, and looks after him, as she attempts to find the owner. Villain: Geraldine Husk.

A former famous manicurist has plotted revenge on a salon for stealing his customers by using his former customers as minions. And Clover unwillingly becomes one of his minions, leaving only Sam and Alex to stop the powerful army from destroying their favourite salon. In the b-story, Clover goes into a pageant for being a Miss Mega Mania. Villain: Manny Wong.

Jerry sends the spies off for a holiday on the WOOHPtanic, but then they realize that time is repeating. Sam was reading a book and every time the same man sit next to her, Alex's hair cut was always gone in the morning and Clover was rejected from the man at the pool. At the end they found out that it was a test. In the b-story, the girls are upset for cleaning their spy outfits after their last mission. Villain: Daniel Nance (Jerry Lewis).

When men start dropping into a dazed sleep, the spies are sent to investigate. They find out that a sexist named Violet Vanderfleet has used an unknown hybrid of poisonous flowers called the Viola Vanderfleetus to destroy the male half of civilization due to her own failed relationships. In the b-story, Sam falls for Clover's ex-boyfriend. Villain: Violet Vanderfleet.

The three richest people in the world are kidnapped and the girls are sent to protect the fifth richest person, the materialistic Milan Stilton (a parody of Paris Hilton) only to find that SHE is the kidnapper! In the b-story, Sam is jealous because of the stars. Villain: Milan Stilton.

Candy Sweet from season 1 "Black Widows" return with her brand new DVD that teaches moves to all the cheerleaders but also hypnotizes them to break her out of prison! After seeing a preview, Clover unwillingly becomes a brainwashed cheerleader. In a b-story, Clover and Mandy compete for Head Cheerleader. Villain: Candy Sweet.

An evil ice cream man makes a special ice cream that contains nitrogen and can freeze anyone it touches. The spies save the day. In the b-story, Alex gets the date bad luck. Villain: The Ice Cream Man.

A former beauty creates beauty products that gives terrible results! Sam and Alex suffer the ill-effects as well. It's up to Clover to save the day! In the b-story, Clover turns herself into ugly girl when she thinks she was rejected. Villain: Miss Vanity.

The spies are sent undercover as farm workers to uncover a plot to turn humans into vegetable-like beings. It's up to the spies to save the day. In the b-story, Clover decides to not be dirty any more. Villain: The Vegan Farmer.

The spies are sent to the moon to rescue a band. It's revealed the blame is the leader of band called Ziggy and he's beaten by the spies. In the b-story, because of her grades, Sam must graduate. Villain: Ziggy.

When Clover, Alex and Sam's mothers discover that their daughters are spies, they completely freak out and inform Jerry that they are putting an end to it immediately. The spies go back to regular civilian life. Meanwhile, Mandy, Dominique and Caitlin all become affected by an evil shampoo from one of the spies' missions (the girls accidentally dropped it into Mandy's pool). Mandy and her cronies become evil “spy-sassins” (anti-spy agents) and kidnap the spies' mothers. Their plan? To sequester them in hopes that they can capture the spies when they try to save their moms. Sam, Clover and Alex realize that their own carelessness is what got their mothers in trouble, so they become spies again and ultimately save their moms. But in doing so, they get captured by Mandy! Now with the spies trapped back at The Groove, Mandy turns them into spy-sassins so that the Sam, Clover and Alex will destroy one another. Luckily for the girls, Jerry trained their mothers to be spies, and the moms swoop in a save the girls from each other. Now with the spies back to normal (thanks to a serum created by Jerry), the mothers and daughters round up evil Mandy and her cronies! In the end, the mothers allow their daughters to remain WOOHP agents.

Clover, Alex, and Sam uncover that Mandy, Caitlin and Dominique have all been affected by an Evil Shampoo that has turned them into "spy-sassins" who have kidnapped the spies' mothers! Will the girls be able to save their mothers successfully or are they to determined to see that this is all a trap to destroy the spies?!

With the spies now held captive by Mandy, things look very grim for them, especially when Mandy decides to turn them into evil spies! What can Jerry do to help? Is there much he can do? Jerry enlists the help of the spies' mothers to save the girls, but can the spies' respective mothers save them from all the mess they've gotten themselves into?

It’s the day before the first day of Spring and Sam, Clover and Alex are at The Groove shopping for a new wardrobe when they come across a mystery vendor selling totally cool bracelets! Happy that they’ve finally found a fashion item that Mandy doesn’t have, the girls eagerly pop them on! The next morning, however, the girls wake up feeling quite strange. What they don’t realize is that the bracelets, were specifically designed to knock out the girls memories of being spies! With no recollection of WOOHP, or their super-spy abilities, the girls go about their lives like normal teens -- allowing the LAMOS to pursue their latest evil plot: to abduct and eliminate Jerry for once and for all! Will the girls be able to piece together the memories of their former lives and save Jerry… or will they remain permanently clueless? Villain: L.A.M.O.S. (Terence Lewis, Boogie Gus, and Helga Von Guggen).

Sam, Clover and Alex finally piece together their former lives but have they done so too late? With the LAMOS already taken Jerry captive and moving in on WOOHP, can the girls stop the LAMOS from carrying out their evil schemes without revealing that they got their memories back? Villain: L.A.M.O.S. (Terence Lewis, Boogie Gus, and Helga Von Guggen).

A blond-haired jewel thief is about to plan a big jewelry heist on the special night Venus aligns with other planets, including Earth. The girls unfortunately fall for his dashing good looks, but realize after failing to catch him many times that they must put his handsomeness behind them and beat him at his own game. In the b-story, Sam won first place in the science-fair and now most of the nerds in Beverly High are chasing after her, demanding she sign t-shirts that have her face on them. Villain: Kyle Katz.

The Bev Hills soccer team coach has retired and is replaced with a new one who has a ball that contains a mind-control chip to create the perfect soccer team. Alex is caught up in the game, turning into a ruthless and crazy player! It's up to Sam and Clover to save Alex. In the b-story, Jerry becomes hooked on video games. Villain: Bonita Bikham.