After Jack receives momentos of his father from an anonymous sender, he and MacGyver launch a search for Jack's mother, who's been missing since he was boy—and they aren't the only ones hunting for her.

MacGyver and an old friend discover a gang ripping off medical supplies from a Phoenix Foundation clinic in Asia, and an Amerasian son the friend never knew he had.

Mac's old friends, the bounty-hunting Colton brothers try to find a young woman who's the only witness to a Chinatown murder, aided by their wise and patient mother, their impatient younger brother and their dog, Frog.