Shirley Daniels returns to the hospital as a patient; Mrs. Craig offers Griffin a place to stay; Chandler and Novino compete to see who can correctly diagnose a difficult patient; and Ehrlich and Papandrao face wedding rumors when they return from Mexico.

It's Halloween at the new and improved St. Eligius, and the craft-matic bed where Mrs. Hufnagel was crushed to death is apparently haunted. Meanwhile, Wade, Craig, and Ehrlich look for a heart transplant recipient and Chandler sucks up to Gideon in order to get promoted.

Craig proceeds with his artificial heart implant despite some questions about his choice of candidates; Morrison tries to deal with the departure of Joanne for Seattle and Dr. Craig becomes suspicious about the relationship between Ellen and Dr. Gideon. AIDS patient, Brett Johnston, and his lover are victims of gay bashing and as a result of his injuries, Brett is readmitted into the hospital.

Phil returns from a training course at the Weigert home office; someone takes a shot at Dr. Gideon; Dr. Craig loses Flash during a rescue attempt by animal activists; the new security cameras upset Rosenthal, who continues to lose control; Novino tries to correct a misdiagnosis made 60 years ago, and a show is performed in the children's ward.

Wade and Kiley liberate their psyches during a study of OR infection vectors; Dr. Auschlander meets the son he never knew; Morrison and Novino grow closer as they work in the ICU; and Rosenthal adjusts to life in the chemical dependency unit.