Katie takes over the ailing "Post-Op!" and her first guest on the show is none other than her GP, bearing news about her cancer. But there's no stopping her now, she takes on her husband, revamps and renames her show - wait for it - "No Show" and casts an Ed McMahon sidekick with a fascination for antennas. Meanwhile, 16 year-old Nicky Sampson strikes out with his high school dream date, but ends up on the bus picking up a voluptuous Polish émigré, three times his age. And if that wasn't enough, Katie's drawn to an angelic boy sleeping on a gurney.

Life thunders along for the Sampson family: Saul begins to atone for his violent past, Nicky's deep in his affair with the Polish émigré, Eli has become a dark prophet of life and death and his mother's chances of survival, while Sarah moves ever closer to realizing the Rapture of Literature and bedding her Lit 12 teacher. Ari holds everything together but cannot control what comes out of the woodwork: Ellie the barfly marches all the way across town with a 35 year-old secret. She's somebody's mother. And Katie? Having held death at bay, she has achieved what all talk show hosts crave: an Oprah-like aura with ratings to match.

Like planes hitting buildings and large waves crashing on distant shores, reversal is the key to life and drama. Katie's cancer comes back with a vengeance. Nicky is busted, but not busted up for his affair with Lenora Bukowski, the sexy Polish émigré. Sarah goes to the edge, but chooses not to seduce her Lit 12 teacher. Saul gives the kiss of life to the young man he put in a coma, while Ari holds on for dear life. Ellie begins to reveal a secret to Eli about the angelic boy. And "No Show" has its final show with Katie Sampson as host.