Katie takes over the ailing "Post-Op!" and her first guest on the show is none other than her GP, bearing news about her cancer. But there's no stopping her now, she takes on her husband, revamps and renames her show - wait for it - "No Show" and casts an Ed McMahon sidekick with a fascination for antennas. Meanwhile, 16 year-old Nicky Sampson strikes out with his high school dream date, but ends up on the bus picking up a voluptuous Polish émigré, three times his age. And if that wasn't enough, Katie's drawn to an angelic boy sleeping on a gurney.

As Katie's show hits new heights, she finds she can't dodge the cancer bullet any longer: her new oncologist orders her to have a partial mastectomy. Not to be outdone by the tumor, Katie decides to have the operation broadcast live. TV never had it so good. Meanwhile, Jane Richards, the sexy producer of "No Show," gets a surprise visit from mother, which leads to a catastrophic showdown with her father and a Mozart concerto.