Lele leaves for Australia while Alice, who will soon join her husband, is in Brazil. Maria meets Guido at the University, a brilliant doctor who is looking for a house and will be hired by the new director at the Local Health Authority.

Maria is very fascinated by Guido, but it seems that the doctor is not interested in her at all. Meanwhile Ciccio, after a prank that risked ending in tragedy, tries to escape from Lele in Australia.

Enrica notices the growing understanding between Maria and Guido and puts a "flea in the ear" of Nonno Libero who begins to worry. Meanwhile, everyone begins to discover that Alberto has not even given an exam at the University.

Nonno Libero does not want anything to happen between Guido and Maria and does everything to keep them away. Meanwhile Alberto is depressed and sleeps in the garage to be alone. He will need the help of the family to get him out of the dark evil.

Cettina sets out to look for Giacinto, discovering a bitter truth. Maria, due to a painful episode, no longer wants to take medical tests. Will Guido be able to convince her otherwise?

Nilde is forced to close the restaurant due to poisoning and notices that Guido is the one who signed the complaint. Alberto, by improvising a nighttime radio episode, manages to get hired on a permanent basis.

A new nutritionist, Carlotta, arrives at the ASL. With her obsessive and detached behavior it is not possible to win her sympathy, and misunderstandings and disagreements arise between her and Guido. Until something brings them back together.

Guido tries to make friends with Carlotta, but the obstacle to overcome is the girl's phobia of physical contact, a difficult difficulty to overcome. Meanwhile, Maria is increasingly jealous of Guido.

Nonno Libero meets Antoinette, the nanny of one of Annuccia's classmates; the child is strangely too calm and Antoinette doesn't understand why, so Nonno Libero invites her to take him to the ASL, to have him examined by Guido.

A mysterious statue found in the garden divides the family. Guido tries to help Carlotta solve her problem, but the situation soon escalates to near disaster.

Carlotta confesses to Guido that she is in love with him, sending him into a crisis because he cannot understand his feelings for Maria. The birthday dinner with the latter, however, skips due to a hiccup.

Maria is happy to have met Gianluca, a charming lawyer, who courts her like a real princess. Meanwhile, some kids enter Ciccio's school at night and break the pipes to skip questions and homework.

Gianluca surprises Maria by taking her to lunch on a boat on the Tiber, which carries a flag with Maria written on it. Meanwhile, Guido has gotten together with Carlotta, and everything seems to be going well... or not?

Carlotta suggests that Guido move in together, the doctor accepts. Meanwhile Maria, having broken off the story with Gianluca, has started working as a volunteer in a recovery center for drug addicts.

Maria is preparing for an exam and is very nervous and Nonno Libero thinks it is Gianluca's fault. Guido and Carlotta continue their story, even if the failed cohabitation puts the relationship to the test.

Nonno Libero picks up the news on the news that a young blonde student has been arrested in Fiumicino together with Gianluca for drug dealing. Thinking it's Maria, he feels bad and suffers a heart attack.

Meanwhile, Guido has problems with Carlotta, tired of seeing her boyfriend totally taken by the Martini family. Maria sees Gianluca in front of her house who tells her he wants to escape to avoid trial.

Guido and Carlotta are increasingly in crisis and during a dinner they argue again. Guido goes to a friend's house who introduces him to two girls and the following morning, the doctor wakes up drunk next to one of the two.

Maria is angry with Guido and disappointed because he betrayed Carlotta. A course on self-esteem is held at the ASL and thanks to it the doctors are able to bring out their problems, especially Carlotta.

Guido and Maria go to get Annuccia from the biopark, but the little girl gets lost. Because of this, Guido does not show up for the appointment with Carlotta, but in the meantime Maria and the doctor finally kiss.

After the kiss at the biopark, Guido understands that he has feelings for Maria but she would like him to leave Carlotta first who, in the meantime, seems increasingly tied to Marcello and not just for work.

Maria is tired of waiting for Guido and decides to go out and have fun with Reby. During a night outing she is stopped by the police and her car is withdrawn. Who's gonna get her out of that mess?

Maria and Guido go to the beach to be alone and when they return home, covered in sand, Libero understands that the two have spent the afternoon together. However, due to an error, Guido is suspended from the ASL.

Maria asks Nonno Libero not to tell anyone about her affair with Guido, but he realizes that in reality everyone already knew. Meanwhile, Guido makes home visits and the patients show up at the Martini house because they only want him.

The story between Guido and Maria falls apart due to a misunderstanding. Even grandfather Libero is furious with the boy, he can't understand that in reality it's not his fault. Guido then decides to make a video to explain everything.

Having lost all hope of getting Maria back, Guido asks for an immediate transfer to Milan and outside the ASL he says goodbye to Marcello and Carlotta. During the journey to the church, Maria realizes that she wants Guido and she runs to the station.

There is a lot of news in the Martini house: Maria and Guido have been engaged for two years and Guido goes back and forth between Rome and Milan, Ciccio still plays rugby and is engaged to an English girl named Emma and…

Nonno Libero is summoned to school because Annuccia has done a decidedly strange essay on the family. Maria rents a house for her and Guido, but discovers that, for now, he is forced to stay in Milan.

Meanwhile, Guido is sad because he has to stay another two years in Milan and doesn't know how to tell Maria, who in the meantime is doing an internship at the ASL. On the way to Milan he has an accident.

Maria misses Guido very much and is thinking of continuing the university in Milan at least until she graduates. Guido meanwhile is trying in every way to get transferred, but it seems that there is no hope.

Cettina and Torello's house is now completed, but Cettina will find some nasty surprises. Maria and Guido have decided to move in together and to keep them from going far Cettina will find an unexpected solution.

The family members decide to give Guido and Maria a whirlpool and a Bohemian crystal chandelier, but the boys get angry because they would like to be the ones to furnish the house. The first quarrels arise.

Between friends and family, at Guido and Maria's house you can't find a moment of peace, and this certainly doesn't do the couple any good. Nonno Libero, on the other hand, due to a series of misunderstandings, thinks that Ciccio is on drugs.

Grandpa Nicola is back in style, but the reality is very different from what he wants to make it seem. He invites Maria on a cruise and she, who initially refuses, finally understands that her grandfather has only her family affection left.

Between friends and family, at Guido and Maria's house you can't find a moment of peace, and this certainly doesn't do the couple any good. Nonno Libero, on the other hand, due to a series of misunderstandings, thinks that Ciccio is on drugs.

Cettina asks Torello to let her nephew Rosalbo join the company, but one night they hear him plotting against them on the phone. The two decide to make life impossible.

Cettina doesn't know how to tell Torello that in reality she isn't pregnant because he is showering her with attention, organizing everything for the future baby. During an ultrasound, she steals footage showing triplets to play along.

Libero is worried about Olindo, an old friend of his who has been missing for days. He learns that he is in a hospice he can neither talk to him nor know how he is. Libero then asks Guido to make an inspection.

Maria has returned from the cruise and Guido immediately fills her with affection, so much so that the two are caught by the entire Martini family immersed in the whirlpool. Meanwhile, Cettina has a decidedly "horror" experience.

Guido is anxious because he has to present the project for the family hospital, but Maria forgets the interviews with the ASL. But the troubles aren't over: the scooter doesn't work, it's a race against time.

Reby tells the Martinis that she is getting married to a Japanese designer she met the week before. Maria is not convinced, knowing the fast falling in love with her friend, but this time it seems serious.

Guido finds a pregnancy test, actually belonging to Reby and, frightened by something he feels is bigger than him, he runs away and leaves himself a note for Maria. The girl, with no news from her for two days, is heartbroken.

A man very similar to grandfather Libero has been wandering around the Martini house for a few days and for grandfather trouble begins: everyone begins to think that he is seriously getting old and does not remember things.

After a check-up recommended by Enrica, grandfather Libero learned that his values ​​are not good and that open heart surgery may be necessary.

Libero writes a letter and delivers it to Enrica with the task of sending it to Lele in case he dies, then both go to the town hall to sign the marriage papers and ask to get married as soon as possible.

The ASL risks closing and all the doctors organize a protest sit-in, which will prove to be useless. Guido, on the other hand, decides to make a request to return to Milan, given that staying in Rome no longer makes sense for him.

While the ASL is being dismantled, the doctors decide to carry out all the visits on the list for free. Meanwhile Guido is nervous and has an argument with Maria. Furthermore, he will be responsible for definitively closing the ASL.

Franco decides to take Maria to a farmhouse, but the same evening the girl, after reading a note from Guido, realizes she is confused and luckily the only thing she is sure of is that she doesn't love Franco.

Guido is looking for funding for the family hospital and decides to organize a heart game to raise funds and at the same time proposes a donation to the bank.

After spending the night with Guido, Maria runs away and confides in Reby, telling her friend what happened the night before. But she also tells her that she's confused that she doesn't know what she's feeling right now.

Guido and Maria are back together and are stronger and happier than before, but he wishes Maria would not leave for Nigeria. He also has a really important proposal in store.

After three years of absence, Lele returns to the Martini house, finding a situation that is not a little indifferent. Thanks to the help of Nonno Libero, Lele will finally be able to become a full-fledged family man again.

Many returns to Casa Martini: Guido has returned to his experience in Africa, Lele returns with the twins. Absent instead Cettina and her family: the former housekeeper Martini has apparently disappeared in a shipwreck.

A nasty surprise awaits Guido and Maria: in fact, the two discover that the tenant of their apartment does not want to return the keys. During a chat, Nonno Libero reveals to Lele that he feels the weight of her old age.

Grandpa Libero left, it's up to Lele to look after the whole family. Elena and Bobò are anxious about their first day of school. Annuccia continues to behave rather arrogantly towards her younger brothers.

Maria is entrusted with the case of a little girl hospitalized for some stomach pains probably due to the absence of her grandfather, who left on a long journey. Maria discovers that the truth is much more painful.

Fanny and Maria become friends, but Maria is jealous because she fears that Fanny will flirt with Guido. She does not imagine that the young colleague is interested in another member of her family: her father.

Maria's pregnancy proceeds and cravings also arrive. Meanwhile, a child neuropsychiatry department will also be opened at the clinic, which is precisely the specialization of the young doctor.

Libero and Enrica return from Puglia for the Christmas holidays. Meanwhile Guido is refractory to the idea of starting a relationship with his newly found mother. Fanny discovers toxic waste dumped in a river.

Guido and Ave have a tough confrontation and the latter makes the fact that she hasn't been there in times of need increasingly weigh on her. Giulio wins the trio in the lottery and an unexpected snow in Poggiofiorito decorates Christmas day.

Maria prepares an exclusive evening for her and Guido, who is forced to stand her up. She feels a bit excluded from Guido's life since she is expecting a baby, and is convinced that he no longer likes him since he has a big bump.

As the last months of pregnancy approach for Maria, Lele feels that becoming a grandfather will be a new adventure, completely different from being a father. All the more reason because Mary's waters break early!

Nonno Libero returns to Rome to meet little Paola. Lele tries to convince Fanny not to continue the relationship, but she is really in love with her.

Giulio convinces Nonno Libero to participate in a new program, Cambio Nonno. Libero accepts and finds himself with a new family, moreover, from Lazio. As a result, that family's grandfather moves in with the Martinis.

The twins notice the silhouette of a woman behind the window of the Torello house and believe that it is the ghost of Cettina. Nonna Enrica, in this regard, organizes a séance to evoke her together with her friends.

A friend of Annuccia surprises Fanny and Lele. Annuccia, after finding out from her friend, doesn't accept her father's new girlfriend, unlike the family who are still a bit confused.

A colleague confesses to Lele that he is in love with Fanny. Lele, embarrassed, does not reveal that he is having an affair with her girlfriend. Meanwhile, Ave tells Guido that her sister did not take well the news of having a brother.

The twins convince Bianca and Lele to go to the Aqua Park, where they hope to make them fall in love. Fanny decides to follow them to get to know the twins well, but they really don't want to know.

Fanny decides to introduce Lele to her family. She has received permission from the Martinis to move into their house, because the maid Melina is unable to look after the child alone.

Bianca receives from the Vatican the task of preparing a chocolate sculpture, but the twins reduce it to crumbs. Lele helps Bianca and, after working all night, the two kiss.

Lele discovers that Fanny's analyzes have been switched and therefore the girl is not pregnant. The two decide to break up and now Lele can stay with Bianca, but the latter is about to return to the Netherlands.

The Martini family is summoned by the police because an American woman asks about them. The Martinis discover that the woman is actually Cettina, even if she seems to remember nothing of her past.

Lele tries, in vain, to get closer to Bianca, hurt by how she was treated by the doctor. She has felt seduced and abandoned by Fanny's pregnancy, and it is hard to forgive.

Maria believes that Guido is cheating on her with Albina, without knowing that she is his sister. Lele makes one last attempt to win Bianca back, but it's too late: she, the latter has to leave for the Netherlands.

The Martini family organizes a surprise birthday for Lele, desperate because he thinks of the woman he loves. Ciccio learns that Tracy has returned to Rome. She can't resist: he goes to see her at the stables!

Guido confesses the betrayal to his wife, who packs her bags and goes to live alone with her daughter, making Guido desperate. Ciccio understands that he is in love with Tracy. Meanwhile Lele goes to London and declares her love for Bianca.

Guido tries to win Maria back, but the girl, when she seems to have forgiven him, sends him a separation request. Lele intends to stay in Rome forever and announces it to the family, who are enthusiastic about it.

The double wedding of Nonno Libero and Ciccio is upon us and preparations are underway. Maria and Guido have to meet the lawyer for a preliminary interview, to talk about the separation. But will it be the right choice?