After escaping from Central Prison, the Freezing Alchemist, Isaac McDougal, sets his plan in motion to kill Führer King Bradley. However, under the command of Lt. Col. Roy Mustang, the military and State Alchemists attempt to stop him.

On the way to Lior, Ed and Al reminisce about the events that lead to them being trapped in their current bodies by breaking the taboo of human transmutation. Meanwhile, Colonel Mustang looks back on the first time he met the Elric brothers.

Ed and Al become interested in biological transmutation after witnessing a chimera in Lior, so Colonel Mustang introduces them to an expert in the field, Shou Tucker, the Life-binding Alchemist. Meanwhile, a serial killer whose targets are only State Alchemists is on the loose in Central.

When the conspiracy surrounding the Philosopher's Stone closes in on the highest ranks of the military, one of Mustang's most trusted and cherished allies is murdered.

In a violent clash with Greed, King Bradley proves to be a brutal opponent. But the man who finally destroys the Ultimate Shield is more powerful than even the Fuhrer himself.

Mustang, Alphonse, Havoc, and Hawkeye split up to search a military laboratory. If Lust has her way, none of them will ever see each other alive again.

Hoping to learn more about the Homunculi, Ed and Al devise a risky strategy to lure the creatures out of hiding. Step one of the brothers' plan: risk death at the hands of their most dangerous enemy - Scar.

Scar's mission to destroy those who slaughtered his people is fueled by justifiable rage. Upon learning the role Scar played in her parents' deaths, Winry claims those murderous feelings as her own.

Cooperation between Mustang's cabal and Ling Yao's band leads to the capture of a Homunculus. Unfortunately, their actions also capture the eye of the Homunculus hiding atop the military's ranks.

Gluttony's twisted powers overwhelm the Elrics - and the creature's appetite is satisfied by battle's end. Meanwhile, Mustang acts on his suspicions of Bradley and finds himself in the belly of the beast.

The Homunculi are winning. Ed and Ling face a horrific enemy within the hellish expanse of Gluttony's gut. In Central, Mustang can only watch as his loyal band of soldiers is divided by Bradley.

Truths are exposed when Al finds the one called Father, and Mustang hears the tale of Bradley's creation - but the most amazing revelation is reserved for Ed after he once again breaks alchemy's greatest taboo.

The Elrics are at Bradley's mercy; if the brothers make one wrong move, those dearest to them will pay. As Mustang quietly gathers allies at his side, Ed discovers there may be no need to find a Philosopher's Stone.

As Edward hears Hawkeye's tale of a time when idealistic young soldiers were tasked with genocide, the horrors of the Ishvalan battlefield are revealed.

A secret encounter allows Mustang to spark new ambition in an old friend - an ally with loyal troops at his command. Meanwhile, Ed and Al share a chance meeting with their biggest fan - young Selim Bradley.

Long ago, the blood of a simple slave was used in an experiment which created a strange, shapeless being. In exchange for the gift of existence, the being gave the slave a name - and cursed him with immortality.

In the snowy north, the soldiers of Fort Briggs engage an invading army, and Marcoh leads an attack against monstrous Envy. In Central, an ominous and shocking secret is revealed to Olivier Armstrong.

Hohenheim and Alphonse enjoy a chance to get reacquainted. Their bond is restored with ease, inspiring the father to share his secrets with his sons - but one of them is far away and on the run.

Quiet warnings spread near and far: the Promised Day is at hand. While most will face the coming chaos with their own kind, Edward forms a new cabal comprised of human, chimera - and Homunculus.

Those who have prepared to reclaim a nation find their plans exposed. The chaos multiplies after an assassin strikes down a mighty leader in broad daylight, and Alphonse falls prey to monsters in the dark.

A rebel victory is imminent and hope takes hold among Mustang and Armstrong's troops. Central's forces teeter on the brink of collapse - until their fallen leader returns to take control.

Central's forces fight with renewed vigor following Bradley's return, and the Fuhrer himself enters the battle. His first opponent is an armored tank. His second foe is even tougher.

The battle for a nation's soul descends into chaos. Bradley unleashes death on those who dare engage him. Beneath Central, the one responsible for the Fuhrer's creation unleashes something far, far worse.

Mustang must make a difficult choice: will he break alchemy's greatest taboo? Or will he watch the person dearest to him die? Meanwhile, it grows ever more difficult to discern where Ling ends and Greed begins.

As the light of the sun vanishes, Mustang learns the loss which comes from seeing the other side of the Gateway - and five sacrifices gather in the dark presence of the Father.

The light is gone. Shadows swallow everything. As the planet quakes and the heavens tremble, the souls of heroes and villains alike vanish into darkness. The circle is complete.

Millions of lifeless bodies litter the landscape of Amestris, and a being with the power to create suns is unleashed upon the world. Unless Hohenheim has something amazing up his sleeve, all is surely lost.