Bugs and Daffy enter a game show that focuses on best friends, but Daffy's bottomless stupidity causes them to lose, which in turn causes him to try and be more like a friend to Bugs. But as expected, he tries way too hard.

Daffy littering the Grand Canyon ultimately sends him and Bugs to jail, which Bugs grows a liking to, but Daffy hates. This causes some conflict when they get the chance to escape.

Bugs and Daffy quickly discover that Yosemite Sam is a less-than-perfect houseguest when they are forced to take him in during a rainstorm. But how to get him to leave?

When the Tasmanian Devil escapes from the local zoo and shows up on Bugs and Daffy's doorstep, Daffy is terrified. Bugs, however, thinks he's just a lost dog and adopts him.

Lola sweeps Bugs to Paris in an effort to fall in love and Daffy discovers that Granny was once a spy in World War II! The coyote tries to catch the Road Runner via speed skating.

After learning about the invention that got Bugs rich, Daffy produces an improvement on it that ends up defective, sending him and Bugs into a financial crisis.

Daffy has found some bowling friends: Marvin, Pete, and Porky. Bugs threatens to end that, which means problems when they enter a bowling tournament, which Bugs joins after Porky is hospitalized.

Daffy has caused so much destruction in the neighborhood, that Bugs has thrown a dinner party so Daffy can say sorry. This won't be easy, as Daffy suspects one of the neighbors of newspaper thievery.

When Bugs and Daffy's favorite pizza joint closes, Bugs reopens it ... and gets in way over his head.

Daffy takes on the persona of his television hero, Steve St. James, while Bugs takes on his caffeine addiction, by switching to energy drinks.

When Foghorn Leghorn takes a liking to Daffy he makes him the CEO of his company ... with disastrous results.

When the overwhelming heat zaps everyone's enthusiasm for Christmas, Lola decides to stage her own version of A Christmas Carol to renew the town's holiday spirit, while Foghorn and Daffy set off for the North Pole to set up a giant fan that will blow cold air down to their sweltering town.

Bugs tells the story of SuperRabbit, with himself as SuperRabbit, Elmer Fudd as Lex Luthor, and Daffy as Zod, and explains why he gave up the SuperLife.