Cat goes into labor with Little Nicky's baby. Little Nicky's advanced aging disease causes him to take on the tendencies of an old man as the disease begins to kill him. Lola Spratt returns from the hospital to explain that she faked her death, but everyone believes she is a ghost. Blake Downs returns to the hospital, following the failure of his private practice/spin-off. New doctor Valerie Flame takes over narrating duties on the show for Cat Black when complications occur in the birth of she and Nicky's child.

Dr. Maestro asks Dr. Flame to give him a lethal injection so that he can find Dr. Spratt in the spirit world. A creepy EMT wants to show The Chief his "sexy costume.

A knife stuck in a boy's chest may not be what it seems; Glenn's cancer cure is threatened by a mysterious visitor, a mind-reading girl visits the coma room.

A boy stuck in quicksand is brought to the ER.

Owen's secret wife (Alicia Silverstone) and baby visit the hospital for treatment; Val plays a high-stakes game of chess.

A day in the life of Chet (Brian Huskey), the creepy paramedic.

Madonna visits the hospital, stunning Owen.

The doctors have free time on their hands. Lola sports a bikini.

Sy's spy past comes back to haunt him when his former partner returns to kill him.

The staff move to an army base in Japan when the hospital is infested with termites.

A plane crash threatens a night of entertainment on the base.

The doctors rally to save a ward for imaginary friends.

Owen learns a lesson about hair choices; Glenn reveals the source of his surgical abilities.

Derek Childrens vows to regain control of the hospital from Sy. Includes fairies, a donkey head, hydraulics and poison lipstick.

Shocking DNA test results cause confusion and chaos among the staff.

Lola may have a superpower, and Blake and Dori seek parenting advice.

Owen and Briggs work together on a murder case that has spanned fifteen years; a look into Owen and Briggs' past.

After a newspaper calls him a "rock star surgeon," Glenn worries that he will die on his upcoming 27th birthday.

When Sy finally gets tenure, he decides to use its powers for the greatest good: building the world's first consumer jetpack. Elsewhere, Chief is stranded on a dance pedestal, and Owen learns just how hard it is to be the hospital DJ.

Blake, Lola and Glenn are excited to be attending this year's Doctor of the Year Convention (or DOY) in Vegas. Even though Blake has won six years in a row, Glenn and Lola are determined to win. Owen tags along to visit his mom, with surprising consequences.

A race horse is wanted by fearsome mob boss Mamma Fiorucci, so Chief hides the animal in the hospital, all while Lola's college barbershop quartet tempts her into rejoining and Glenn glues Blake's hands into his latex gloves. VALERIE HARPER and WILL SASSO guest star. Recurring guest star BRIAN HUSKEY also appears.

In a "Behind the Scenes" episode, actor Just Falcon (who plays Dr. Glenn Richie) invites the rest of the Childrens Hospital cast to his special photography exhibition, where all of their shocking secrets are revealed.

It's "Bring Your Grandparents to Work Day" at the hospital. The doctors struggle with their grandparents, whether they're overbearing, trying to kill themselves or are just famous actors.

When Glenn and Owen experience bizarre hallucinations and Lola fears she's being followed by an imaginary doctor, they think a gas leak in the hospital might be to blame. But what they discover threatens to upset the entire future of Childrens Hospital.

When Glenn and Owen experience bizarre hallucinations and Lola fears she's being followed by an imaginary doctor, they think a gas leak in the hospital might be to blame. But what they discover threatens to upset the entire future of Childrens Hospital.