Longworth and Carlos are called to investigate the murder of a psychic advisor in the eerie town of Cassadaga, founded over 100 years ago by mediums and psychics; Callie's friend asks Longworth to be her date at a party for Callie's medical school.

Longworth's latest investigation into the death of a young girl puts him at odds with a powerful political family. It appears she was having an affair with a Florida State Senator. Complicating matters is the Senator's wife who will do whatever it takes to promote her husband's political career and protect her family's name

Longworth teams up with his old partner, Detective Samantha Harper to track a serial killer from Chicago and Callie can't help but notice the obvious chemistry between them. Manus asks Callie to work as a forensic nurse for the FDLE.

Longworth investigates a murder in Gibtown, a community populated with human sideshow descendants, and everyone is a suspect. Jim and Callie try to figure out the exact meaning of their relationship.

Jeff's mentor, the high school soccer coach, is found shot dead on campus.