Throttle, Modo and Vinnie...The Biker Mice from Mars...escape their planet as it it devastated by the fish faced plutarkians. Crashlanding in Chicago, the renegade rodents soon discover the Plutarkians next target: EARTH. Led by his supreme chessiness, Lawrence Limburger, and his devilish cohorts, Greasepit and the fiendish Dr. Karbunkle, the Plutarkians are already undermining the Windy City. It's tail whippin' time 'cause the baddest motorcycle mammajammers in the universe are riding to the rescue.

Limburger frames the mayor's kidnapping on the Biker Mice, so he can take over the city.

When Modo is covered in toxic substances, Limburger escapes with his bike. Modo does not want to rest while Charley and the guys rescue his bike.

The Biker Mice realize that Limburger is not the only evil character in town, when they attempt to stop a bank robbery. Vinnie must descend into the Pits to save his brothers from the Pit Boss.

When Limburger disappears mysteriously, his unintentional replacements turn out to be increasingly more powerful and evil.

In order to steal all the steel from the town, Limburger offers Modo a new arm to work for him.

The Heavy Metal mouse that the mice despised on Mars, heads into Chicago, but with an all-new attitude.

After losing his funding, Limburger has a wonderfully devious plan to get back in the High Chairman's good graces, and this leads the mice and Charley in a race to save a national monument.

Limburger's old Plutarkian rival, Napoleon Brie arrives on Earth to try and take over operations.

When the Biker Mice finally capture Limburger, they must return with him to Mars to face trial. They discover that they are also thrown in prison for treason. The Mice have to escape and save Charley from Greasepit and Karbunkle while claiming that they have not done anything wrong.

The Mice must now face Limburger's latest machine from annihilating Mars. The machine attracts asteroids to the planet, to bring complete destruction.

They still have to roost Napoleon Brie from Chicago where he's taken over in Limburger and the mice's absence.

When intergalactic game hunters catch Modo's nephew Rimfire, he manages to escape in their ship and finds himself on Earth.

The Mice and Charley must travel to Kansas to stop Limburger from stealing all the grain from the nation's breadbasket.

The Pit Boss is back with a new friend, framed for a crime he did not do, while the Pit Boss captures Charley.

Throttle's ladylove lands in Chicago to steal the last remaining specimen of a plant that is desperately needed for the Martian ecology to survive.