11 year old Chyna starts her first day at High School as part of the Advanced Natural Talents (ANT) Program. There she meets Olive (who is smart) and Fletcher (who is a good artist and has a crush on Chyna). Chyna's two new friends help her learn the ropes of her new school. But, Chyna of course doesn't fit in. So, she decides to sneak into a party and show the High Schoolers what shes got. But, Olive, Fletcher and Cameron (Chyna's brother) might ruin her chances.

Chyna decides to get involed in some clubs and sports and joins Cheerleading. Inspired by their friend Olive and Fletcher start a lunch club.

Fletcher tries to impress Chyna, but she is too concerned about Gibson after he tells her that he has been feeling lonely. Chyna and Fletcher find out that Sofie, Gibson's ex-girlfriend from his childhood, is in jail for a robbery. So they take Gibson to the jail to show him that Sofie is a criminal, so he can get over her and hopefully stop spending all his time with Chyna and Fletcher. Meanwhile, Lexi tries to get on the front page of the news, but must show Olive that she's done something newsworthy.

Chyna falls for a new student in the A.N.T. Program from England. He's another artistic genius who goes to school as a robot. But when Chyna tries to ask him out, he asks for advice from Fletcher. Chyna tells Fletcher there's a artistic guy that she is secretly in love with, and if she should ask him out. and Fletcher thinks she is thinking about him. But when he finds out that Chyna and the new kid from England are going out, Fletcher gets help from Angus to sabotage the date. Meanwhile, Darryl challenges Olive and Cameron at the arcade to see who can get the highest score on a game, Donkey King.

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It’s Halloween at Webster High School and it’s Chyna Parks’ first day in the Mutant Program, where monsters go to school with normal high school students. Chyna is Medusa so she fits right in with her new Mutant Program friends: Olive, a mad scientist, Fletcher, a vampire and Angus, a zombie. However, Lexi and the normal kids are terrified of the mutants, so Gibson pairs everybody off to help prepare for the Halloween dance.

Olive loses her memory after hearing a loud noise and is kicked out of the A.N.T. Program by Principal Skidmore.

Chyna and Lexi both get picked as finalists for the reality show "America Needs Talent" and they end up having to pretend to be best friends.

Chyna and Fletcher go on a double date together. Meanwhile, Gibson takes over as cheerleading coach

Olive and Fletcher exclude Chyna from their product idea. Meanwhile, Paisley gets attention from her injuries and Lexi get jealous.

Olive is shocked to discover that her pet robot, Hegel, is no longer functioning and has suspicious screwdriver scratches on his back. When a screwdriver is found in Chyna's locker, Chyna suspects that she has been framed and vows to find the real culprit. In the end, it is revealed that Chyna accidentally overfed Hegel.

After creating a really sad animation, Chyna advises Fletcher to do an animation on something he's familiar with, so he creates an offensive animation about Olive, making her an ant named "Pimento". It gains major popularity, and Olive is majorly offended, so she tries to offend Fletcher back, but that doesn't work out so well. After Olive issues a lawsuit on Fletcher for offending her, they go to student court, where they learn to be friends again, and start teasing Chyna. Chyna takes it okay, so they all hug and make up. Cameron joins the beauty club to keep Vanessa away from other boys, but things go horribly wrong.

The ANTs go to an Australian ANT convention. Coincedentally, Lexi and Paisley went to Australia for vacation, but were stuck at the ANT convention. At the convention, Chyna sees an Australian Nature prodigy named Neville, who has a show, where his name was Tazmanian Neville. Fletcher wants to prove that he has "manly skills", so he asked an Australian supervisor, who dropped him off in the middle of the Australian Outback. Chyna, Olive, Angus, and Neville go to save him, but then learn that Neville is actually an Acting prodigy, who knows nothing about nature. Olive suggests to throw a boomerang to hunt birds, but it doesn't work. Chyna suggests to crack "rocks" together to make fire, but the "rocks" were actually emu eggs. Later on, the 4 of them hide in an old car, when they discuss how much they miss Fletcher. Just when they thought Fletcher was not ever coming back, they saw him riding on an emu. Chyna starts to tell Fletcher that she'd might actually- Just then, the boomerang came back and hit her on the head. Meanwhile, Lexi and Paisley dress up as nerds and participate in the ANTlympics.

The ANTs take the IQ test; Olive is devastated when Chyna scores higher. Olive retests to receive a higher score, but she doesn't do so well. Olive decides to dumb herself down and starts acting like a dumb blonde. The next day, she has transformed into a mini Paisley, acting just as clueless as her. Meanwhile, since Chyna got the highest IQ score in the entire school, Principal Skidmore chose her to represent Webster High in the Acadecathalon. Chyna is completely lost, so Olive steps in and takes her place. It is revealed that Angus hacked into the school computer and messed with Olive's IQ test results to lower her self-esteem to finally go out with her. Elsewhere, hoping to be excused from P.E., Lexi and Cameron train to compete in curling in the Olympics with Gibson and Violet.

Webster High is completely deserted due to the teachers getting food poisoning from the cafeteria. The ANT's are the only ones at school, and instead of attending class, Principal Skidmore sends them on an educational scavenger hunt around San Francisco. After Chyna and Lexi are chosen as team captains, they pick their teams, and head off. Now, both teams compete to see who comes out victorious.