Professor Crumhorn returns and uses his transformation pills to turn himself into a little girl in an attempt to get Danger Mouse to break into Fort Knox.

Just when Penfold should be meeting his Aunt and the airport, he and Danger Mouse are sent to the Amazon jungle where a tribe have been sacrificing people to The Great Ant God from Ataxia. Penfold is captured, and things look grim, but then Penfold's Aunt arrives from a taxi and tells them all to stop playing silly games.