After he is summoned unknowingly by Ben Pitcher to treat one of his cows,a human patient of Doc's dies. Durning a fight with Pitcher, Doc is knifed.

Doc comes upon a homesteader (Philip Bourneuf) with a busted leg and a gun to protect himself from his wife (Cloris Leachman).

Matt leaves Dodge City unprotected when he sets out to find a killer (Mike Connors) (Bert Rumsey credited as 'Bartender', but referred to by Chester as 'Sam Noonan').

Matt helps a woman (Constance Ford) whose suitors (including Denver Pyle) are about to duel for her affections.

A landowner (Paul Fix) tries to terrorize homesteaders (Bartlett Robinson and Peg Hillias) off their land (Gordon Gebert, John Smith, and Stuart Whitman appear).

An old buffalo hunter (Edgar Stehli) swears revenge on the skinner (Grant Withers) that left him to die (Richard Deacon appears as banker Botkin, Bert Rumsey credited as 'Bartender').

An Indian woman (Angie Dickinson) faces prejudice for her father's raid on Dodge City (Peter Whitney and Paul Wexler appear).

A bank robber (Robert H. Harris) murders his wife and frames Tobeel (Frank de Kova) for the crime (Paul Lambert appears).

A young gunfighter, Tom Clegg, forces farmer Abe Curry into a duel and kills him. Matt can't arrest Clegg since Abe drew first. However, Abe's brother Morgan plots revenge. Morgan, who is unarmed, follows Clegg constantly. Clegg soon grows tired of it and attempts to take care of his ""problem.""

The shooting of several members of an outlaw gang, though in self defense, triggers an emotional crisis in Matt, haunted by memories of all the men he has killed (Lawrence Dobkin, Russell Johnson, and Gloria Marshall appear).

Rena Decker, a new dance hall girl, purposely gets her admirers into fighting over her. Despite Kitty's negative opinion of her, Matt befreinds Rena and gets her a job at the Long Branch. Soon afterward, 4 men are dead and Rena is the cause.

A cowboy vows revenge for the shooting of his friend, who was mistaken for a criminal (Don Keefer and Catherine McLeod, real-life husband and wife, appear as a husband and wife).

Matt fakes his death to lure a gunman (Vic Perrin) out in the open (Robert Karnes appears, Bert Rumsey credited as 'Sam').

A former gunfighter has turned away from violence, but his fiancee's brother is determined to goad him into a gunfight.

Joe Delk causes trouble at The Long Branch after shooting two men who were unarmed.

Matt goes after an outlaw (Earle Hodgins) who shot Chester (Paul Wexler appears).

Kitty's father, Wayne Russell, arrives in Dodge to meet his daughter after abandoning her and her mother as a baby. He insists that saloon life is not fit for a proper lady and wants to take her back to New Orleans so he can pamper her and invest her savings in his freight business.

A braggart tries to provoke a gunfight with a harmless drunk.

Jack Kelly plays a hot-tempered husband who thinks Matt is after his wife.

Doc, Chester, and Matt suspect Kitty of helping a bank robber when she invites Matt to an out of the way spot for dinner. What they didn't know was that the bank robber was the first 'man' Kitty had ever known.

Jesse comes to Dodge to kill the man who killed his Pa.

Trail boss Dolph Quince sends for his friend Matt to help escort his cattle herd into Dodge because he is having trouble with Jayhawkers (Kansas renegades), and he hopes to ease the animosity his men have towards all Kansans.

When Onie Becker is shot down on the streets of Dodge after quarreling with Al Clovis in a poker game, everyone thinks Al Clovis committed the shooting.

The plot thickens after Matt and Chester pursue Clovis on a train headed out of Dodge.

After years of captivity, a white woman and her half-Indian daughter are set free by the Indians, but they are shunned in Dodge.

A gunfight in the Long Branch forces Matt to arrest a drunk. Letting him go since it was a fair fight, he suspects him of selling guns to the Indians, and goes after him even though he may run into those Indians.

Matt and Dodge City's businessmen employ an unusual tactic to save ambush victim Lee Prentice from being taken to corrupt Baker City to face certain hanging on a trumped-up murder charge.

Matt becomes suspicious when Jerry Cass's plans to marry saloon hostess Bella Grant are complicated by Bella's sudden insistence that Jerry leave his recently-inherited ranch for six months.

Gunman Kin Creed arrives in Dodge determined to enhance his reputation by outdrawing Matt in a gunfight. He goes to great lengths to force Matt into a confrontation and is able to wound him, but it proves to be a pyrrhic victory.

Seriously injured Matt faces a moral dilemma when Blue Horse saves his life and prevents the escape of a prisoner. The Marshal knows that Blue Horse is being sought by the Cavalry as a fugitive from a reservation, and he is well aware that he is duty-bound to assist their search in any way possible.

Ironic tragedy results when Danny Kader stubbornly disregards his father's predispositions (and Matt's pragmatic advice) in order to attempt an elopement with a young gypsy woman.

Horses with Bar S brand are being sold to unsuspecting buyers. Deesha moves in to claim the horses, leaving the buyer with nothing.

Matt, escorting 3 men back to Dodge, claims a beautiful wounded Indian woman will be able to identify the one who shot her and killed her husband.

Matt is uncertain what to make of Cyrus Tucker's confused claim that his wife of 32 years "just ran off", especially when a homesteader claims that he saw the old man digging a large hole just behind his house.

A father threatens to kill the two drifters who have been plaguing his daughter.

An ex-Confederate waits to settle the score with the Union man whose unit cost him a loved one and property in the late war.

Despite a serious heart condition, onetime prizefighter Tom Burr is determined to go through with his plans to fight vicious Hob Creel. The only way Matt can stop the mismatch and save Burr's life is to fight Creel himself.

Matt has reason to believe that the new overweight, gun toting, straight shooting, female owner of the Lady Gay saloon may have killed the previous owner, or did she?

Old man Onie has a great swimming cow that can lead herds across rivers, and when they both come up missing, one trail boss accuses another of killing them.

Determined to avenge his murderous brother's hanging, Vince Walsh begins a self-serving campaign of unofficially helping to keep the peace in Dodge City over Matt's objections. Walsh is certain that his actions and his taunts will eventually goad the Marshal into a gunfight.

When the greedy relatives of a dying man (Crowbait Bob) learn that he might be dying, they come to Dodge to grab anything of value they can get from the dying man.

Far from Dodge, Chester finds himself in the uncomfortable position of trying to extract a bullet in order to save Doc's life after the two are ambushed by a pair of savage prairie wolfers.

A saloon girl shoots a man who came to her room, claiming he attacked her, but as the dead man was to testify against a man from the woman's past, Matt is suspicious.

There's a cattle drive near town, and the cowboys are nervous about a series of cattle rustling events that have taken place recently.

The widow of a stagecoach robber is courted by the man who, unbeknownst to the widow, is the one who shot her husband.

Troublemakers trick an immigrant blacksmith into leaving his house on his wedding night, then burn it down.

Matt arrests Finn Pickett after recognizing his face from a wanted poster. On the way back to Dodge, Pickett's vengeful sons try to free their father as Matt and Chester face a water shortage.

Lee Nagel suspects his visiting uncle of murder when his father is killed in their store in an apparent accident.

While transporting a prisoner with Chester on a stagecoach to Wichita, Matt learns that the stagecoach is also carrying a shipment of gold, and he suspects the coach might be targeted by outlaws.

Out on the prairie, Matt is shot and taken captive by two outlaws, one of whom is a weakling abused and bossed around by the other.

Jake Creed accuses his young hired hand, Ben Tolliver, of horse theft.

A man shoots his partner, flees, and is caught by two men claiming to be lawmen.

Dillon goes after cowboy Jake Bayloe after he guns down his partner in the Long Branch , shooting Kitty in the crossfire and critically wounding her.

A horse thief murders a man to get his horses. Matt tracks the criminal to a Kiowa camp.

A gunrunner supplies the Pawnee with weapons. Matt arrests him, but when the Pawnee find out, they capture Matt and free his prisoner.

A hard man has given his two sons a hard raising, sure that they inherited their mother's bad blood from their murderous ancestor. The old man may be right: one of his sons may be a murderer. Or is it the other son?

A headstrong young woman will undertake the long, dangerous journey to her fiancé's fort on her own if she must, so Matt nominates himself to escort her.

Matt escorts a captain and his troops to an Indian village, to make an exchange for a white woman captured over a year ago.

Prospector Harvey Easter settles in Dodge City after striking it rich in the Colorado Rockies. His heavy handed attempts at philanthropy soon have unintended results.

Cody is a well-liked citizen of Dodge. He's building a house and getting married. When he befriends a stranger, his perfect life is turned upside down.

Beginning with Doc, who rescues him from a ditch, everyone wants to give amiable drunk Dan a chance, or a job, or both.

While returning suspected killer Pruit Dover to Dodge to stand trial, Matt is shot and badly wounded, and yet Dover stays with him and nurses him back to health.

A group of women are going by wagon train to Colorado, lured by the promise of marrying rich miners, but Matt learns that the leader's actual plan for the women is quite different.

Loy has always felt he could do what he pleased. When he shoots one of his gang members in the back just for the reward, he takes the body into Dodge to Matt Dillon who isn't as ready as he thought to give him his bounty.

Henry and Jake have struck it rich. Now they want to follow their dream and buy a Mississippi river boat. When Henry spots Miss Kitty, he fancies marrying her but she will have nothing to do with his dream or him.

A charmer escapes from federal prison to Dodge and finds himself caught up in the drama among two brothers, the wife of one of them, and their domineering father.

A half-Comanche has joined his mother's tribe in killing whites to avenge the murder of his father, but Matt sees the good in the man and the chance to re-integrate him, perhaps, into white society.

A bank robber hides out in Dodge, bringing along his girl. While he's gambling away his loot, his girl casts her eye on Matt.

A trapper leaves his friend dying alone in order to save his own life, only later to stumble across that friend in Dodge, very much alive and wanting him dead.

A band of ne'er-do-wells, led by their mother, see in town a young woman that pleases them and decide to take her by force.

Civilization is moving in on the isolation of a rugged pioneer friend of Matt's, and he starts using lethal force against the settlers encroaching on the land he regards as his.

When a boy witnesses his grandfather's murder, it sends Matt looking for a new found companion's uncle. Festus Haggen is tracking his uncle for killing his twin brother Fergus. Matt is wary but learns to trust Festus when he's shot and in bad shape.

A slick city reporter sets out to prove that even a milquetoast can pass for a feared gunfighter, if a few well-placed tidbits of rumor precede him.

Quint says that white renegades, not Indians, are the cause of recent raids around Dodge. Working shotgun on the stage, he proves his point when he is attacked, then pursued by those renegades. His "Indian" skills save him and a colonel's daughter who has contempt for half-Comanche Quint.

O'Ryan and Finnegan, feuding over a girl they both knew back home, are caught in a legal loophole to take ownership of a mine and land they both own. When Matt is forced in the middle of it, he has to work fast so no one else is hurt.

A rancher's spoiled son believes even after he is convicted of murder that his father's wealth and influence will save him from the hangman.

A woman newly widowed is powerfully attracted to Quint, but when he gently turns her down, she vows to make him pay for scorning a white woman.

Aaron, sweet on saloon girl Leah and wanting to make her his wife, is attacked and killed by Colie Fletcher. When Matt goes after him, Colie runs into Jubal Tanner, wounds him, and steals his horse. Jubal, ungrateful to those who help him, meets Leah, and each helps the other's outlook.

A young man is convicted of killing the saloon girl he wanted for his own. Matt is so sure that the young man is really innocent that he goes on the road after another suspect to prevent an unjust hanging.

A charming cowboy apparently is guilty only of breaking hearts until he gets to Dodge, where he finds two women who may make a killer of him.

A mild-looking cowboy discovers that it's easy to steal, and, soon thereafter, that it's easy to kill as well.

Festus returns to Dodge from wolfing and is hired by the Cattleman's Association to hunt down the wolves killing everyone's cattle. What he finds is that what's been doing the preying may wind him up in prison if he doesn't get Matt's help.

A man is stabbed after winning in a poker game, and Festus is suspected.

The Ginnis family causes trouble for Doc Adams, because they hate waiting. Will Timble gets hurt at The Long Branch. Doc has to remove Will's hand, which causes Will to leave Dodge because he can't carve wood anymore.

Festus' cousin May Blossom arrives from Texas to marry Festus

A family in search of a doctor find Matt and his prisoner unconscious and handcuffed to each other on the prairie. The prisoner wakens first and announces that Matt is the condemned man he is transporting for hanging.

Festus finds a little girl out on the prairie. He learns she saw her mother get killed by a stranger. When he takes her to Dodge, Matt hears she was hiding when this happened but can identify this man who may already be in town.

Festus, returning to Dodge after doing some trapping, sees his girl, April, and they argue over a gift she received. Running off, she hides but her perch gives her a bird's eye view of a murder, one no one believes she witnessed but the killers.

Henry Huckaby, a local farmer and fed up with a sore back and an empty belly leaves to seek his fortune in Dodge. After several failed ideas he hits on one that may make him rich but could also cost him his life.

A traveling salesman meets up with Bull Foot, an Indian who mainly sells vegetables. When goods are traded for a squaw, he is upset when she runs away and into the arms of Festus, whose mule she steals, only to return home awaiting sale to the next customer.

Jess, Jay's twin, is shot and killed by an unknown assailant while working late at the family business. When a stranger to Dodge is suspected, Matt does his best to track him down and bring him to justice.

Cyrus Degler is determined to keep Quint away from his 19-year old daughter, but no threats or beatings can keep them apart. They are about to leave town to get married when cousin Praylie comes to town bent on putting a stop to their plans any way he has to.

Mistakenly hailed as a hero who downed four robbers, a man rethinks his decision to let folks regard him as a gunfighter when protecting the woman he wants calls for a gunman's skill.

Bert Clum uses his clan to get what he wants. They are camped outside of Dodge. When they meet a small wagon train, he hatches a plot to rob the local bank. But he needs to snatch a baby to hide behind first.