Who’s-Who invites Drake and Hawkins to a plot to kill Queen. Meanwhile, the Straw Hats are facing two large monsters that remind them of the Giant who they once struggled to take down. As Luffy charges towards them, someone unexpected comes in to help.

Drake vows to fight alongside Luffy, but Zoro becomes skeptical and challenges him to a fight. Meanwhile, Usopp’s practical joke pushes Nami into confronting Ulti, who is infuriated since her brother got attacked.

Queen uses a new version of the Plague Bullets which will turn the samurai into ogre-like monsters. Meanwhile, the Minks keep pushing the fight against the Gifters and drive Jack into a corner. However, Kaido stands up for his subordinate.

While Luffy is hurrying to the rooftop and Yamato is trying to catch up to Momonosuke to protect him, the Akazaya members finally face off against Kaido. Hearing Kaido jeering at them for being weak, the samurai retainers attack him relentlessly, remembering the day Oden told them to master his sword skill.

Queen, the Lead Performer, blazes away at samurai on the Performance Floor with the special version of the Plague Rounds, which turns them into hideous ogres that corner Zoro and Drake. Meanwhile, Luffy and Sanji, who are on their way to the rooftop, run into another Headliner with a special ability.

King orders his subordinates to go after Momonosuke. Shinobu tries to protect him, but they are cornered by one of the strong Lead Performers from the Animal Kingdom Pirates. Meanwhile, seeing people suffering from Queen’s Plague Rounds, Chopper is determined to save everyone.

Yamato fights Sasaki and the Animal Kingdom Pirates Armored Division to protect Momonosuke. Meanwhile, Zoro tries to get rid of the Gifters who have turned into Ice Oni, but Queen starts a horrible game which involves the antibody for the virus.

Ulti and Page One of the Tobi Roppo chase Nami and Usopp, after being infuriated by their attack as well as Luffy’s declaration of becoming the King of the Pirates. Cornered, Nami gives in and Ulti pushes her to say the unthinkable.

Carrot and Wanda step in to help Marco, who is cornered by Big Mom and Perospero. In the meantime, Yamato fights a fierce battle against the Animal Kingdom Pirates Armored Division led by Sasaki, while protecting Shinobu and Momonosuke.

Zoro and Drake continue to chase Apoo to get the antibody against Ice Oni, while Chopper is trying to figure out how to fight the virus. In the castle, Luffy, Jimbei, and Sanji are climbing up the stairs to reach the rooftop where the Akazaya members’ tough battle against Kaido rages on.

Sanji hears a woman’s scream for help and dashes into the room the scream can be heard from. However, it’s a trap set up by Black Maria of the Tobi Roppo. Meanwhile, Luffy and Jimbei who are trying to reach the rooftop get help from the unexpected.

While Kaido begins the New Onigashima Project, Marco appears in front of Chopper and the others, who are struggling with Ice Oni. The members of the Tobi Roppo continue to give the Straw Hats a hard time while their former member helps Zoro.

Yamato tells Momonosuke and Shinobu that he once confronted a man, who came to Onigashima looking to get Kaido’s head. His name was Ace. The two of them engaged in a fierce battle that eventually turned into an important friendship.

The formidable Lead Performers of the Animal Kingdom Pirates stand in Zoro’s way as he tries to get to the rooftop. Marco sees his late comrade in Zoro’s determination and tries to pave the way for him.

Yamato tells Momonosuke and Shinobu about how Ace gave him hope for the future. Meanwhile, Luffy and the other allied pirates from the Worst Generation make it to the rooftop to finally face off against Kaido and Big Mom.

Luffy’s strong attack reminds Kaido of all the strong ones he’s ever met. On the other hand, Luffy, Law, and Kid keep quarreling amongst themselves. Meanwhile, Sanji is caught and interrogated by Black Maria in what he calls “heaven.”

Luffy, Law, Kid, Zoro, and Killer keep landing hard blows against Kaido in tandem despite the arguing. However, when Big Mom steps in and unleashes powerful lightning strikes, the tide turns for all except one of the rookies.

Luffy pummels Kaido with his well-trained Kong Gatling and delivers a final blow using all his strength. Big Mom tries to fight back, but Law gets in her way and Kid and Killer also try to finish Kaido off.

After watching the Straw Hats’ departure to Onigashima, Tama wondered if there was anything she could do to help the Straw Hats and the samurai. Now that she’s here on Onigashima, it’s time to execute her powerful plan – Operation Kibi Dango!

Sanji is captured and tortured by the merciless Black Maria. She names the terms of his release: to turn over one of his crewmates. He hesitates but has no other option. After much distress, he makes a move that surprises everyone.

Robin bursts in to rescue Sanji along with Brook, and faces Black Maria, who is trying to keep Sanji as her pet. Meanwhile, Yamato, Momonosuke, and Shinobu are spotted hiding by the enemy, and they find themselves on the run again.

Chopper works hard to make the cure for Ice Oni, even though he is turning into one himself. Meanwhile, the infected Boss Hyogoro the Flower regains his youth and fights fiercely to protect Chopper and the others.

Seeing everyone turning into Ice Oni, there is nothing that the samurai warriors can do other than grieve. However, it wasn’t just them who were devastated by Queen’s raging virus. When their desperation and frustration peak, they hear a hopeful voice.

That unparalleled laugh! The Akazaya regain hope upon witnessing Oden's return. They failed in their attempt to take down Kaido, but after twenty years, they team up with Oden again to finish the job!

The Akazaya members run to save Momonosuke, but an unexpected contender stands in their way. Queen gets infuriated after Chopper ruined his plot and goes after him. Meanwhile, on the rooftop, Kaido and Big Mom unleashes a combination attack on Luffy and the others.