With a new, powerful entry in the race, Kane and his people flex their political muscles to maintain their hold. Meanwhile, a worried Meredith suspects her husband is keeping something from her.

Kane finds himself starting to lose control, both politically and personally, as his supporters begin to question their confidence in him. Zajac ventures into uncharted territory while campaigning as Miller continues to dig for answers.

Tom Kane cements his mayoral legacy with a lavish ceremony celebrating the groundbreaking of the new modernized O'Hare terminals. Now Kane looks to the future, setting his sights on reviving a subsidized housing project. While his political future seems bright, Kane continues to battle for control over his disease.