In the pilot of Smash we are introduced to Tom Levitt and Julia Houstona song-writing duo who had planned on taking a break from the business of Broadway but, find themselves drawn back in when they get the desire to produce a musical based around the life of Marilyn Monroe. When a demo of one of the tracks goes viral the project attracts the eye and ear of tenacious producer Eileen Rand and, although causing a conflict that of director Derek Wills. But the biggest and most important task is to find their Marilyn after, auditioning a range of girls they whittle it down to two but, who do they go for. Ivy Lynn a veteran of the stage who wants to break away from the chorus line to get her break as a lead or Karen Cartwright a fresh talent who is trying to follow her dream of becoming a star.

Ivy and Karen jump through hoops for the brilliant but temperamental director Derek Wills as they pursue the role of a lifetime. Meanwhile, Julia and her husband Frank, are frustrated by the red tape of an international adoption process, and Eileen fights to finance her new musical in the midst of an acrimonious divorce.

The search begins for a Joe DiMaggio to play opposite Marilyn - but everyone's first choice, Michael, has a secret. Karen returns to Iowa for a baby shower and must decide what she wants for her future. Eileen begins rounding up investors - but ex-husband Jerry may already have poisoned the well.

Karen finds herself seduced by the glamorous life of new BFF Rebecca Duvall -- but can Rebecca be trusted? What will Karen's ascent mean to her relationship with Dev? And will Rebecca drive Derek insane? Eileen introduces new beau Nick to ex-husband Jerry, while Julia panics when her son Leo goes missing.