Julienne修女和Turner医生在是否提供私人护理服务的问题上发生了冲突，而一次令人痛苦的分娩引起了人们对另一个沙利度胺事件的担忧。

当一位孕妇向她倾诉时，Frances修女发现自己处于一个棘手的境地。Julienne修女的新事业遇到了绊脚石。

Hilda修女和Turner医生与一名年轻女子发生了关系，她的健康状况出现了一系列的挑战。一次复杂的怀孕使Nonnatus团队走上了一条探索之路。

现在是1966年7月，英国正处于世界杯的热潮中。新的助产士学生Nancy颇有影响。

由于Hilda姐妹外出参加进修课程，Julienne姐妹介入进行家访。新的助产士学生们适应得很好，空气中弥漫着一种希望。

在一次例行家访中，Julienne修女为孕妇维拉-桑兹（Vera Sands）做检查时，对她刚学会走路的女儿感到担忧，因为她出现了令人不安的症状。Julienne姐姐和Turner医生决心找出问题所在，并开始着手调查。

同时，一位过度保护自己的母亲努力应付她女儿的少女怀孕，并坚持要保持低调，这让新来的助产士Nancy Corrigan很是沮丧。

这是1966年9月，在诊所里，Trixie负责检查一个怀有第五个孩子的绝望的妇女。Trixie了解到她的病人的个人生活远非稳定，迫使她公开发表意见。然而，这些结果在Nonnatus House和社区中引起了不同的反应。

Turner医生和Frances修女受托帮助一位拒绝医疗服务的准妈妈度过怀孕的最后几周，Nancy Corrigan透露了她的背景秘密，这可能威胁到她与Julienne修女和Nonnatus House的关系。

Nonnatus之家在努力接受Nancy的启示。Julienne修女在母院休年假，Hilda修女很高兴有机会掩护她，并以她的领导能力给人留下深刻印象。

在照顾一位孕妇时，Frances修女和Trixie修女震惊地得知白杨镇的住房危机正在恶化，这让Nonnatus团队发誓要为变革而奋斗。

对Turner一家来说，这是一个悲痛的时刻，因为Timothy准备去爱丁堡的医学院学习，Cyril收到了来自家乡的消息，促使他和Lucille考虑自己的未来。

与此同时，一个非常特别的婴儿出生了，他在一个亲密的家庭中造成了裂痕，并导致许多人开始计算他们的祝福。

Christmas promises to be a memorable one at Nonnatus House as Lucille and Cyril prepare for their upcoming winter wedding. The Nonnatus team are faced with their busiest Christmas Day ever as the Maternity Home is filled with expectant mums-to-be, each with their own challenging case. Luckily Mother Mildred is on hand to support the team.

Demolition work in Poplar uncovers a long-buried secret that leads to a testing and emotional case for the team. Sister Julienne takes on a sensitive delivery.

At the monthly cytology clinic, Sister Frances comforts a young woman who is struggling with a life-changing diagnosis. Lucille supports a difficult mother.

Shelagh organises a special celebration to mark 100 years since the Order first arrived in Poplar - although Sister Hilda feels that she should have been in charge of the festivities. Nancy tackles the plight of meths drinkers living rough in Poplar, and Nurse Crane treats a young singer who is torn between two very different futures.

Sister Hilda and Dr Turner support a young father with a lung condition whose wife is planning a home birth, and discover he is also coping with the repercussions of a past trauma. Cyril looks for a job that will put his qualifications to good use, a first-time mother struggles to bond with her daughter, and Fred comes up with a way to keep the wards cool during a summer heatwave.

Trixie has been assigned to a complicated case involving a crane driver who was injured in a workplace accident and is now paraplegic. Meanwhile, Nancy and Sister Frances give a talk on the facts of life at a primary school, and Lucille's attendance at a straightforward delivery takes a distressing turn. Shelagh decides to organise a jumble sale to raise money to fix some broken playground equipment in the park. When Sister Julienne finds a suspicious item, chaos ensue

Sister Monica Joan seeks advice from a clairvoyant. Matthew is shocked to discover squatters in one of his warehouses, and Shelagh faces the most challenging delivery of her career.

Nonnatus House suffers its biggest threat yet. But this time it’s not the bricks and mortar that are in danger, it’s the people.

Nonnatus House faces its darkest day after a tragic incident in the heart of Poplar. As the community rallies together, the team must overcome personal anguish to help the injured.

April 1968. Racial tensions cast a shadow over Poplar, Nancy’s eyes are opened when she supports a dying woman, and Nonnatus House welcomes a new sister.

Sister Julienne helps care for a first-time mother who is going through a challenging diagnosis. Lucille struggles with her own health, and Poplar celebrates the Whitsun Maypole.

Sister Veronica is shaken when a mother reveals a terrible truth about her marriage, whilst Shelagh cares for a baby with a life-threatening condition and Nancy harbours a secret.

The maternity home is thrown into chaos by an outbreak of gastroenteritis, and Nurse Crane fights to save her career. Meanwhile, Cyril encourages Reggie to seek help.

A pregnant mother with a chronic heart condition falls unwell, Nancy grows suspicious of a young father’s erratic behaviour, and Matthew prepares for a visit from his father.

Trixie supports an underage mother through a difficult time, Monica Joan welcomes an unusual guest to Nonnatus House, and Sister Veronica spearheads a new council initiative.

Poplar’s housing crisis deepens, bringing a sad case to the attention of the team, whilst a worrying disease outbreak directly impacts the residents of Nonnatus House.

Dr Turner experiences the biggest test of his career, while Trixie’s approaching nuptials cause stress levels to escalate. Sister Julienne hatches a plan to save Nonnatus House.

As Poplar prepares for Christmas, Sister Monica Joan fears this could be her last. Dr Turner and the midwives deal with a complicated multiple birth, and Cyril helps a war veteran.

Sister Julienne cares for an expectant mother who has cerebral palsy. Nonnatus House kicks off its new midwifery training scheme with the arrival of four new pupil midwives.

The team help a single mother whose flat is riddled with damp whilst Nancy and Dr Turner care for a Sylheti woman with an undiagnosed illness, and Matthew teaches Trixie how to drive.

Nurse Crane helps a struggling first-time mother accept her baby’s birth defect, and Violet’s bid to be mayor is thrown into turmoil by unforeseen circumstances.

Trixie makes a serious mistake at work, whilst the team work hard to help a Biafran family. Nancy delves into her family’s past as the world celebrates the moon landings.

A fun day at the seaside proves traumatic for the Turners and puts May’s future with them in jeopardy. Nurse Crane helps a young couple cope with a rare cancer diagnosis.

In his new role, Cyril faces his toughest challenge yet, whilst Matthew is summoned to a board meeting with his mother. Elsewhere, the pupil midwives prepare for their final exams.

Rosalind oversees the care of a teenage mum and uncovers a disturbing truth. Trixie and Matthew struggle with their change in fortune whilst Joyce receives an unexpected visitor.

Miss Higgins receives an unexpected visitor, and Sister Monica ruffles feathers. Poplar votes for its Mother of the Year.