Pierce and Moretti take on an extraterrestrial case when a woman reports that aliens have abducted her husband. When Pierce and Moretti arrive to investigate, however, they make a startling discovery. Meanwhile, things heat up between Pierce and his real-life girlfriend, Caroline, but his relationship could be jeopardized if he can't get his imaginary girlfriend, Natalie, out of his mind.

When a series of bizarre public murders occur, Pierce realizes that the killer is trying to send a message about inattentional blindness, but Donnie doubts this theory. But Pierce has a trick up his sleeve that can prove his point, and they must scramble to piece together the clues before the clever killer can make any more examples out of innocent victims.

Pierce accepts an invitation to work on a case from a renowned environmental activist concerning a chain of abnormal neurological reactions in a group of young girls. However, upon examining the girls, Pierce discovers that a dark secret is at the root of their ailments. Meanwhile, Moretti questions Pierce’s motives in working on a case without her.

When a prosecutor mysteriously drops dead in the middle of a courtroom, Pierce and Moretti go on the hunt for a killer. Meanwhile, Moretti and Donnie make some decisions about their future.

After a young victim with a developmental disorder is taken hostage in a bank robbery, Moretti brings in Pierce to interview the boy. When they finally track down the culprits, they discover the case is about much more than money. Meanwhile, Pierce’s estranged father James pays him a visit.

Donnie and Moretti are caught in the crossfire when a sniper shoots up the lobby of the Federal Building. When Pierce determines that the shooter is afraid of Extreme Low Frequency radio waves, he and Moretti take a trip to the Quiet Zone in Virginia, where they think the shooter is hiding out. Meanwhile, an alluring woman named Shelby Buchanan courts Donnie to run for political office.