When the FBI takes on a case of disappearing college girls, Jack Crawford recruits Will Graham, a gifted criminal profiler with a unique view into the psyche of serial killers, to consult. Jack also seeks the help of Dr. Hannibal Lecter, a brilliant psychiatrist. After a copycat strikes, Will and Hannibal join forces to track down the culprit.

Will and Jack race to apprehend a serial killer using humans as fertilizer.

Abigail Hobbs comes out of her coma with new information about her father.

A series of family murders takes place.

A deadly symphony hall killing forces Will to hunt a defiant killer.

Will, Jack and the BAU team hunt for a serial killer who creates a totem pole out of his victims' bodies.

When Dr. Gideon escapes to terrorize Alana and Dr. Chilton, Hannibal and Will go on the hunt. Eddie Izzard guest stars.

Hannibal frames Will, convincing Jack and Alana that Will's the copycat killer.

Springing their trap, Jack, Will and Alana face off with Hannibal in a bloody final showdown, but the doctor has a few surprises of his own.

The FBI's search for elusive serial killer Francis Dolarhyde intensifies as Will Graham begins envisioning himself in Dolarhyde's tormented psyche. Wading deeper into dangerous territory, Will enlists the help of Hannibal Lecter to assist with the killer's profile. Meanwhile, Alana Bloom reminds Will that the last time that he and Hannibal worked together things didn't end well, but Will sees no other option. Elsewhere, a new woman comes into Dolarhyde's life.