Rhoda Reynolds is charged with murdering her blackmailing ex-husband, Arthur Kane. At the trial, Perry moves the proceedings to the room in which Kane was murdered in order to re-enact the fatal night.

Martin Ellis is sent to jail for stealing the sum of $300,000.00. Ellis is later exonerated thanks to evidence discovered by his wife and the real thief, Charles Brewster, is arrested for the theft. Brewster manages to get out of jail on bail but later turns up dead. Ellis is charged with the killing.

Danny Ross is a television comedian who is waiting to hear about a new television show. It has been three years since his last television show was cancelled. Charles Goff is an advertising executive who promised Danny he would pitch him for a new show in return for an introduction with the president of a large big-budget advertiser. Danny does his part but learns from Goff's secretary that Goff landed the deal without him. When Charles Goff is found dead in his office the next morning, Danny's friend, Freddie Green, is accused of the murder after finding his fingerprints on the murder weapon.

Evelyn Forbes escapes from a mental institution only to be charged with murder. The key to the case is a dog that continues to howl no matter what.

Ruth Prescott wants to divorce Walter Prescott so that she can be with her true love, Jimmy MacLaine. After a brush with death, Ruth becomes convinced that Walter is trying to kill her rather than give her the divorce. Walter then turns up dead and the police are convinced that Ruth shot him but Perry, as usual, doesn't think so. A lame canary and unusual bruises on the victim hold the keys to the puzzle.

Bruce Chapman returns home early from a business trip to find that his wife, Marie, wants a divorce. Chapman is shocked at this turn of events because just before he left on his trip he thought he had found the strangled body of Marie in his office. But if Marie is still alive, who was the dead woman in the office?

Marjorie Cluny wins a contest for best looking legs sponsored by Frank Patton of Stellar Productions. Her prize is a trip to Hollywood and a role in Patton's next picture. Unfortunately, there was fine print in Marjorie's contract and her Hollywood career lasts only two days. Patton is then found stabbed to death with a woodcarving instrument . Marjorie disappears and becomes the leading suspect.

DA Hamilton Burger asks Perry to defend an old friend who once saved his life in a boating accident ten years before. The old friend of Burger's is now facing a murder charge.

Mason is sought out by land tycoon Adam Thompson, who suspects one of his nephews of rifling the house safe. The twist? The land tycoon's next in command is found dead, after it's found out that he was the one stealing the secrets.

Jim Ferris is having an affair with his uncle's bored young wife. They concoct a scheme to finagle $80,000.00 from the uncle by faking a kidnapping. Things go horribly wrong when secretary Betty Wilkins, acting as a go-between, is charged with the murder of Jim Ferris.

Lester Martin's life takes a horrible turn for the worse when a man breaks into his apartment, forces him at gun-point to drink half a bottle of Scotch, and then drives him into the country. Lester's circumstances then go from awful to good grief when he's charged with the murder of his step-father who was trying to takeover the family boat company.

Slimy publishing tycoon Donald Fletcher buys controlling interest in a respectable but financially troubled publishing house. Fletcher turns things upside down by turning the publications into scandal sheet featuring photographs of scantily clad women. Edmond Aitken, whose family once owned the publishing house, wants to oust Fletcher but Perry tells him he has no legal basis on which to do so. Not to worry. Fletcher is found murdered in his apartment but the prime suspect is Aitken's wife, Alyce, whom Fletcher had been blackmailing over lurid photos Alyce made during her younger days.

Phony psychic Phillip Paisley meets a grisly death when an elevator that has been tampered with crashes. In the climactic scene Perry sets up another fantastic demonstration to prove his client innocent and expose the real culprit.

A really weird courtroom confession scene highlights this episode about the murder of a race car driver.

Axel Norstaad sells his much respected furniture trademark to Martin Somers, described by some as the slide trombone of the furniture business. Somers immediately begins stripping the company of its assets and churning out inferior products. Axel protests these developments vehemently and when Somers is found murdered he gets arrested for the crime. To complicate things, Axel is in love with Edie Morrow whom he suspects might be the actual killer.

Ted Chase discovers that his bitchy second wife, Irene, might have killed his first wife and contemplates revenge but someone else gets to Irene first. In his defense of Ted, Perry discovers that Irene's past was even more sordid and corrupt than previously believed.

A crazy man (or is he?), his dead nephew and a military base are tangled up in a confusing Perry Mason episode.

Young cop Jimmy Anderson, cousin of Lt. Anderson, and veteran Otto Norden come across a robbery at the Wilson Plastics Company while on patrol one night. A shooting occurs and Otto is killed. Evidence then points to Jimmy as having been an accomplice in the burglary and he is suspended from the police force. Then the night watchman at Wilson Plastics, a disgraced ex-cop, is found strangled to death. Lt. Anderson then asks Perry to look into things and defend Jimmy against all charges.

Two brothers at separate times have claimed the same young girl as their daughter. One brother owns a fleet of tuna boats; the other is a mobster. Then banker Franz Moray reveals that $100,000 due to the girl via a trust fund has been mishandled. When Moray is found murdered Perry steps in and discovers an old family secret.

Professor Lindley is in a pit of trouble when he tries to help a kid dodge a murder rap.

A promoter's plan to frame his wife and business partner for embezzlement fails, but they're arrested anyway for his murder.

Mason's client: an amnesia victim on trial for the murder of her husband.

The deceased father of Alice Trilling left behind a strange will. His successful toy company would be left to her ONLY if Alice is married or engaged within a year's time. Until then, her wheelchair bound Uncle Harry and a board of directors will run the company. In searching for a husband, Alice has one major problem: she's coyote ugly and she's the first one to admit it. An artist begins a flirtation and after seeing a portrait he's painted of her, Alice begins to think she could find happiness with him. There's one problem though: nasty old Uncle Harry has been playing matchmaker behind the scenes for reasons of his own. Alice discovers her uncle's perfidity and pushes over his wheelchair. Quickly fleeing the scene, Alice is later arrested when Uncle Harry is found dead. Perry is retained as defense counsel but even he has a tough time in this one because Alice herself thinks she's guilty.

Uninterested in her recently inherited fortune, an aspring singer is easy prey for a sinister agent.

Balancing private investigation with legal gymnastics, Mason tries to iron out a case of embezzlement and murder.

Tryon Laboratories hires the Drake Detective Agency to protect their latest formulas. In spite of Paul's best efforts, there is a leak in security and some top-secret information is stolen. One night, Leigh, an undercover agent working for Dr. Scranton, the head of the company, calls to say he knows the identity of the spy. Scranton and Paul rush to the laboratory only to find Leigh dead, floating in a vat of water.

Things keep going from awful to good grief for poor Ethel Andrews. First she's left at the altar by her fiancé, Bruce Strickland, who also let's her take the blame for a $50,000 securities theft since her signature was on the transfer authorization. Ethel decides to leave town but nearly has an accident with a car driven by Peggy Sutton. Peggy, it seems, is on the run from a hired killer. Ethel foolishly agrees to swap identities with Peggy but then Peggy perishes in a car accident. Ethel then finds $50,000.00 in the trunk of Peggy's car and makes the mistake of informing Bruce Strickland who turns up murdered. Perry sends Paul Drake up to Lake Tahoe to find out about Peggy Sutton but it might be too late because the noose is getting pretty tight around poor Ethel's neck.