Chemist Randolph James has started a successful company to develop a new antibiotic but his former boss, Hudson Bradshaw, files suit claiming that James developed the formula while in his employ. James' wife, Natalie, then begins selling her stock to Bradshaw which would give him control of the new company. James vows to stop his wife at any cost and she turns up dead. James claims that he was fishing at the time the murder occurred but things go from awful to good grief when he can't find the fellow fisherman who can substantiate his story.

A man's campaign to prove his estranged wife an unfit mother is interrupted when he's arrested for murder.

Mason is caught in the middle when a romance develops between two members of rival political families.

Drake gets more than he bargained for when he agrees to act as courier in the sale of a rare Confederate coin.

In Hawaii to handle an investigation for a hotel chain, Mason and Drake uncover a murder.

Pete Warren's estranged wife, Myrna, is killing time in Reno waiting for their divorce to go through. When Myrna gets involved in a counterfeit gambling chip scam, Pete makes the mistake of lying to protect her.

In this change of pace episode Perry and Della travel behind the Iron Curtain and get involved in a murder case which ends up being tried in an East German court.