As a lethal powers-enhancing drug is unleashed on the public, Detectives Walker and Pilgrim seek out the criminal mastermind behind it with the help of iconic Power, Retro Girl. As clues come to light, Walker considers the possibility that Wolfe, his dangerous former mentor turned nemesis, might have the answers he seeks.

Johnny realizes that's his new drug is dangerous, but is it too late to stop Wolf before all hell breaks loose?

As Retro Girl, Zora and the heroes of the world rush to stop the escape of Wolfe from The Shaft, Walker realizes he must face him alone, the inevitable clash between mentor and disciple that will unravel the deep-seated history between them.