When Alex is forced to put a patient’s gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart. Charlie deals with a patient who is healthy, sane – and convinced she is going to die at midnight. Meanwhile, Joel secretly helps Sonja deal with a patient of hers who’s been admitted to Hope Zion Hospital.

Alex, Maggie and Joel face a mystery; Charlie meets a patient with an usual link; an unexpected visitor has Zach questioning his abilities as a dad

Celebrated neurosurgeon Thor MacLeod gives Alex an offer; Charlie deals with a fatigued spirit; Joel ends up in a fight at the clinic.

Charlie tries to treat two female MMA fighters; a fight between Dana and Molly ends up in the hospital; Dawn must save a woman's heart.