Iria visits her home province of Batabitajira, only to be attacked by a Zeiram-produced clone. Yet Iria senses that somehow, this encounter with the Zeiramoid being was no accident, and somehow, it was waiting for her...

Meanwhile, citizens of the Capital City of Myce are disappearing at an alarming rate. Worse still, it seems that more and more hideous creatures are being unleashed upon the city. And at the epicenter of all the activity stands Zeiram, who can not only produce genetically cloned beings to do his bidding, but also call more Zeirams from beyond the Mycean planetary system...

Severely injured during her last battle with Zeiram, Iria finds herself more reluctant to go after Zeiram -- at least not without some advantage she might be able to use. But Kei is not so cautious. Frustrated by Iria's apparent lack of initiative, Kei decides to go after Zeiram herself, only to be stopped by Fujikuro.

Meanwhile, the Mycean council's plan to build a huge transemmbler is met with forceful opposition by the Zeiramoid clones. Zeiram has resisted every know weapon on the planet, and the only plausible solution seems to be to transport it off world, and make it someone else's problem. But Iria knows the only solution is to stop Zeiram permenantly...