Mindy thinks she finally meets the perfect guy, Jaime, only to find that he's way too close to his female best friend, Lucy. Then, when Danny gets dumped by Jillian, he tries his best to get her back with the help of Morgan.

Mindy's friends and co-workers unintentionally throw her the worst birthday party ever. And, after storming out, Mindy stumbles upon a new group of friends with whom to celebrate. But when she ends up in a fight with her new pals, she receives help from someone in her recent past. Meanwhile, Danny and Jeremy compete for the affection of Mindy's friend.

Danny gets caught sneaking out the office supply of painkillers for his troublemaker childhood friend Stevie who has instant chemistry with Mindy. Meanwhile, Mindy is in for a shock when Heather, Josh's ex-girlfriend who ruined Mindy's Christmas party, shows up at her doorstep to ask for her blessing to move into her apartment building. Mindy says yes, but immediately begins to plot ways to ruin Heather's rental application.

When Mindy decides to have a night out by herself in the city, she hits it off with a stunningly handsome man who turns out to be a prostitute.

When Danny's ex-wife, Christina, comes back to New York to confront Danny about an emotional letter he had written to her, Morgan confesses that he had sent the letter unbeknownst to Danny, causing Danny to fire Morgan out of anger. Meanwhile, the rest of the staff compete in a triathlon and go head-to-head with the midwives, who have hired Morgan to work for them.

Mindy makes the bold decision to move to Haiti with Casey for a year, much to the amusement of her co-workers. In order to prove that she can survive in rough conditions, Mindy invites herself and Casey on a camping trip with Danny and his ex-wife, Christina, with whom he has recently reconciled.