Dana treats an HIV positive patient of Lu's when Lu is out of the clinic and learns that his mother took him off the HIV medication with Lu's permission. She is furious and reports the mother. Although the boy suffers terrible side effects from the medication, Dr. Bob Jackson insists that he be put back on it. Dana falls for her handsome intern.

Dana's former beauty queen patient doesn't think her husband finds her attractive and insists on having extensive plastic surgery. Dana refuses to perform the surgery but when Terri Ann lands in the ER, she begins to doubt her decision. Peter tries to figure out why a transvestal is having side effects of menopause and counsels Marc about one of the stickier issues of adolescence. Lu and Lana try to find an appropriate punishment for two young teenagers who spray graffiti outside the hospital.

Lu coaches a teenage basketball team and is troubled when a player faints at a game. She later finds traces of steroids in her blood and wonders if the entire team is on the drugs. Dana is mystified when a complete stranger shows up in the ER with Dana's name and phone number in her purse. Dana must make a difficult decision for the women and regrets that she can't find her family so they can decide.

It's Breast Cancer Awareness Weekend at the Rittenhouse Hospital Women's Clinic, where Lu (Rosa Blasi), Lana (Jenifer Lewis) and Peter (Josh Coxx) are hosting a dance-a-thon and a free mammogram clinic. When one woman's mammogram reveals a lump, she must choose between losing both her breasts and losing her job. After Dana (Janine Turner) delivers the unexpected results of her breast cancer clinical trial, she learns the very disease that's defined her career has now hit too close to home.