Eric's strange post-surgery behavior leads him to make a life-altering decision that shocks and worries Annie. The reverend considers another calling when the ministry begins to lose its appeal. His plan to abandon his religious duties is hatched after a new neighbor mistakenly calls him Mr. Camden. Fed up with everyone bringing their problems to him, Eric becomes more and more apathetic toward his family and community. Meanwhile, Lucy turns to the new associate pastor for advice when she sees Kevin and Roxanne having too much fun dancing at the pool hall. Concerned when he can't find Lucy, Kevin interrupts Simon and Cecilia's date to enlist their help.

Eric gives Annie his manuscript to read but she's not happy to learn that he's been spending his time writing smut instead of his comeback sermon for the church. Meanwhile, Simon and Cecilia discuss having sex for the first time and naively share the news with their parents---which doesn't go to well when Cecilia's father finds out. Lastly, Lucy sets out to spy on Roxanne and Chandler on their first date.

Eric begrudgingly agrees to see a therapist in order to appease Annie who is at her wits' end with him. Meanwhile, Simon is ecstatic when Cecilia's father agrees to let him see Cecilia, but feels hurt and confused when she starts avoiding him. Roxanne becomes suspicious when a pretty girl seeks council from Chandler. Lastly, Ruthie is shocked to learn that her new upbeat friend Katelyn suffers from cystic fibrosis.

Annie is plagued with curiosity about what goes on during Eric's therapy, but panics when his doctor invites her to attend one of their sessions. Meanwhile, Lucy tries everything to get excused from jury duty, upsetting Kevin in the process when her views of the judicial system are different from his own. Also, Chandler confesses the extent of his feelings for Roxanne after she is stabbed on the job by a homeless man. Lastly, Ruthie fears that her parents may be heading for divorce court after overhearing them fight.

Lucy confesses to her dad that it will break her heart if he doesn't perform the ceremony at her wedding and he struggles with the decision to return to the church. Meanwhile, Simon catches Cecilia's father's business manager stealing from petty cash. Roxanne's policeman father tries to bully Chandler into ending his relationship with Roxanne. Ruthie and Peter try finding Ben a girlfriend with his training dog, but things go awry once they lose the dog. Annie hijacks Lucy's wedding by making all of the decisions herself without paying attention to any of Lucy's wishes.

After Ruthie's boyfriend Peter grows more suspicious of his mother's new fiancé, Reverend Camden steps in to counsel the threesome and get to the root of their problems. Meanwhile, Chandler provides pre-marital counseling to a couple who don't seem destined for the altar; Cecilia confides to Simon the reason she doesn't want her parents to renew their wedding vows; and Roxanne tries to convince Chandler to return home to see his dying father.

Eric and Annie throw a "Welcome to the Neighborhood" party for Ruthie's Muslim friend Jill Dupree and her parents, but the Duprees are hesitant to attend. Eric is shocked and disappointed when he learns that his neighborhood is not a friendly place for Muslims. Meanwhile, Cecilia's house is robbed while she and her dad attend Kevin's first Neighborhood Watch meeting; Roxanne mentors a troubled sixteen-year-old and suspects that he might be involved in the robbery, and Chandler finds himself attracted to Peter's mom Paris.

Annie's half-sister Lily shows up on her doorstep to discuss an important family matter after Annie refused to contact her. Eric tries to figure out why Annie won't contact Lily. Meanwhile, Cecilia sets Martin's friend Mac up with a girl from school, but he doesn't want to go out with her because of something embarrassing that happened ten years ago; Ruthie and Peter put a bad spin on a school project that lands them in trouble when they create a newspaper featuring false and derogatory stories about two former US presidents. Lastly, Roxanne turns to Chandler when she finds herself faced with a moral dilemma as she is keeping a secret from Kevin regarding Detective Michaels.

The Camdens, especially Lucy and Ruthie, grow concerned that an unusually joyful Annie isn't dealing with her true emotions following the death of her father Charles, but the happiness proves to be infectious as it soon spreads through the family and all over town. Meanwhile, Eric tries to convince an unhappy Chandler that he should consider adoption. At the same time Chandler is approached by a mysterious young girl who gives him a cryptic message before she disappears.

Lucy finds her husband Kevin and his partner Roxanne in a compromising position while on an undercover police assignment, Cecilia and Martin's relationship hits another bump in the road when their after-school commitments get in the way of one-on-one time, and Chandler may have bitten off more than he can chew as a new parent. Ruthie and Peter get stranded after missing their bus during a school field trip. However, fate intervenes when the youngsters cross paths with Lost Boys Nicodemus and Jacob, who not only take care of them until Reverend Camden arrives, but also share the heartbreaking story of their struggle to stay alive.

The Camden chaos continues with Matt, who is trying to salvage his marriage, questioning whether he still has feelings for his ex-girlfriend Heather; Simon's return to Glenoak creates conflicted feelings for his ex-girlfriend Cecilia, who is torn between her feelings for Simon and her current boyfriend Martin; Ruthie's foreign exchange student friend Maria, appears to be making the moves on Ruthie's boyfriend Peter; and grandparents-to-be Eric and Annie hop a plane for New York, despite Mary's repeated pleas for her family to stay away.

After discovering that Mary (Jessica Biel, who does not appear in the episode) has filed for divorce and signed away custody of her son, Matt is at a loss for how he should to break the awful news to Eric and Annie. Simon informs his new girlfriend, Rose (guest-star Sarah Thompson), that he won't have sex with her, but avoids telling her the reason behind his decision. She gets fed up with him but comes back to him when she finds out his true intentions for them---marriage. Meanwhile, Ruthie's boyfriend, Vincent (guest-star Thomas Dekker), asks Martin to get Ruthie to break up with him.

Also, Eric gets involved once again with the Davis family children when little boy Danny (guest-star Drake Johnston) is being adopted by Cecilia's parents, George and Gwen (guest-star Brad Maule and Holly Fulger), but forgets to mention that the kid is part of a package deal as Danny has three sisters in Social Services as well, and try to take them in as well. Kevin is about fed up with Lucy as he's fr

When Simon and his new girlfriend Rose (guest-star Sarah Thompson), make an unexpected visit to Glenoak to meet their respective parents, Annie begins to suspect their relationship might be on a fast track. She let's them know they are not allowed to sleep in the same room together in the house as they spend the night. Rose puts up a fight with both Annie and Simon over the sleeping arrangements, but eventually take will. Meanwhile, Eric hides the news of Mary's (Jessica Biel, who does not appear in the episode) divorce, worried that it will most certainly break Annie's heart.

Also, Martin becomes the third wheel again in Ruthie and Vincent's relationship as Ruthie thinks Martin is jealous of their relationship despite the fact that Vincent wants Martin to convince Ruthie to dump him. The adoption process for George (guest-star Brad Maule) and his wife over the Davis children becomes more complicated when their biological mother fights for the adoption process to not happen. Lastly, Ma

Eric meets Sandy's father, who gives him an envelope of money intended for Sandy; and Ruthie collects soup-can labels to help her school's newspaper. Elsewhere, Simon has money troubles and his phone service gets shut off; and Martin has a heart-to-heart talk with Meredith about their future. Sandy: Haylie Duff. Meredith: Megan Henning. Edward: Michael McDonald. Beau: Costas Mandylor.