Eric develops a child-like fascination with life when he takes a much-needed vacation after his heart attack episode, while Annie runs into interference with each of the kids. Meanwhile, Simon assumes the role of the 'man of the house', but feels Matt is undermining his authority when he keeps on making fun of him. Also, Matt grows uncomfortable with the blossoming friendship between his girlfriend Shana and his roommate John Hamilton while he's busy with other issues. Also, Lucy finds a direction in her life with her interest in Habitat for Humanity after taking her fathers advice.

When Ginger pays the Camden family a visit, she informs Eric and Annie that her father is in the early stages of Alzheimer's Disease. At first, Annie can't believe it, but after observing him in the backyard and not paying attention to a fire in the barbecue, Annie realizes the truth. Meanwhile, Mary and Eric can't see eye-to-eye on her relationship with Robbie, but they soon agree to compromise. When Mary informs Robbie of the plan, he tells her that it won't work between them. Fortunately for Mary, Robbie changes his mind after talking to Eric in the local grocery market. Also, Lucy gets into trouble after blowing off a Habitat for Humanity project to go on a date, and is caught. Meanwhile, Matt is consumed with depression due to Shana's upcoming move to New York. By this, Matt pays no attention to Simon, who just wants to spend time with his big brother. Also, Ruthie makes a vast millenium preparations until Eric provides her with a more grounded perspective.

Rev. Eric Camden counsels a sexually molested girl to help her express the rage and pain she's been hiding from her family. This dark secret that Mary knows about weighs in on her, which brings her to open up to Lucy. Meanwhile, Simon and Ruthie learn the power of communication with their friends and classmates. Also, Matt helps Hank reveal an important personal secret to Julie before his mother visits.