A notorious gangster is preparing to turn State's evidence when he is murdered, but Ironside pretends that the man is still alive, and ready to talk, in order to catch the killer and nail a major criminal.

As the team passes through a small town, Ed is kidnapped by an escaped convict. When it transpires that the real criminals are the local law officers, the pair go on the run together, and Ironside must get to Ed before he is killed by the Sheriff and his men.

A policeman is shot and killed by an assailant. The evidence points to the murderer being a local thief, currently enjoying a reign of terror in San Francisco, but soon the investigations lead elsewhere.