Weaver becomes concerned about Greene's cognitive skills and surreptitiously calls for an official evaluation of his competency. Corday plans her wedding to Greene. Bishop Stewart returns, and Kovacs realizes the man has a terrible disease. Dateless for a charity function, Carter invites Abby to attend with him.

Abby and Carter travel to Oklahoma to rescue Abby's mentally ill mother and bring her back to Chicago. In Chicago, Maggie suffers from a sleeping pills overdose. At County General, Kovac frantically revives her. Benton treats a college student injured in a fraternity prank.

Cleo and Carla clash after Reese gets hurt while in Cleo's care. Weaver and Kovac cannot save the life of a developmentally challenged woman's only caregiver. Abby goes to a therapy session with Maggie. Later, Abby confesses to Maggie that she is afraid to bear children because they might be bipolar like her mother.

Corday's ordeal, caused by the recent infection-related deaths of several of her patients, worsens when she is closely observed by a stern taskmaster. Corday is outraged when a county investigator accuses her of deliberately euthanizing the patients, who all happened to be elderly.

Benton commits perjury on the witness stand in order to gain custody of Reese. When Romano refuses to give him a more even schedule, Peter resigns and seeks a job at the clinic where Cleo is newly employed. Benton is granted custody of Reese and he and Cleo decide to move to the suburbs together. Meanwhile, Carter's father visits for Christmas with the news that he's getting divorced, Weaver and Sandy Lopez finally go on a date, and Abby catches Nicole in the maternity ward, recovering from an abortion.

Drs. Corday and Greene are awkward when working together in the ER. Dr. Weaver treats victims of an intense fire that may take the life of a dear friend.