Benton has a very extraordinary and interesting case when he comes across a boy with reversed internal organs.

Greene flies in a helicopter to a remote area of Indiana to rescue a heart transplant patient. The helicopter develops problems, and Greene arranges for paramedics to transport the patient to County. Because Weaver is gone for the day, Romano appoints Benton in charge of the ER. Kovac is plagued by the death of the mugger.

Dr. Weaver is in a difficult situation when an alderman tests positive for syphilis. Dr. Carter is impressed when he meets a man who runs an inner city clinic.

Ben Hollander is a distraught architect whose degenerating eyesight causes him despondent while a spirited new nurse, Samantha Taggart joins the staff. Elsewhere, disaster strikes when the doctors suspect a mother is abusing her child while Dr. Corday learns something shocking about the charismatic Dr. Dorset, and Dr. Archie Morris is overwhelmed by the chaos and grisly conditions of life in the E.R.

Neela is still struggling with her decision not to continue becoming a doctor. We discover that Ray is in a band. Kovac and Sam are amoureux, but where does that leave them?