Klaus returns to the French Quarter of New Orleans, a place where he helped build centuries ago. Now he sees that it has been taken over by his former protege Marcel. Camille, a psychology student, doesn't believe in supernatural beings. However, she finds herself drawn to Klaus. Meanwhile, Hayley and Elijah wait to see what Klaus will do next.

Determined Rebekah is on a mission to get to the bottom of a recent strange encounter involving Elijah. Davina convinces Marcel to let her attend an annual street music festival.

Hayley goes missing after someone from her past makes a startling revelation. Klaus has a dangerous encounter with an unexpected visitor. Davina makes a surprising connection. Marcel makes Rebekah an enticing offer that leaves her torn.

Tension between Marcel and Klaus results in Marcel refusing to help Klaus with a gruesome discovery in the Cauldron. Rebekah revisits her past when she finds the remnants of a sacrifice by the docks - the work of a dangerous warlock she has come across before. Klaus battles, but his opponent has an unfair advantage.

Marcel and Rebekah fret over whether secrets hidden for nearly a century are about to be exposed. Father Kieran deals with a witch from his past. Hayley and her werewolf clan enjoy a party. Sophie discovers something shocking at the cemetery. Klaus takes some dangerous measures that will affect everybody.

Since the original vampires were stuck in the cemetery, Klaus takes any chances to punish his sister with the Original-killer stake.

Cami feels threatened, as Marcel rallies an army to take back control of the city.

Klaus wants Hayley to re-establish herself in her pack. Mikael is impatient under Davina. Cassie arouses suspicions.

Cami teams up with Marcel and Gia after she becomes suspicious of her faculty advisor Vincent. Lastly, in a surprising turn of events, Klaus comes face-to-face with a visitor from his past.

Rebekah becomes interested in a girl. Hayley struggles with coming clean and is surprised by something Jackson admits. Klaus learns something and heads to confront Hayley. Vincent sets his eyes on Marcel for answers to what Klaus is hiding.

Following a tense run in, Elijah believes that Klaus is up to something. Kaleb needs Rebekah's help.

With the knowledge that he has been betrayed by his siblings, Klaus and an unlikely friend plan to get even with them.

Months following their violent and deadly showdown with the powerful witch Dahlia, a rift continues to divide brothers Klaus and Elijah, while Freya searches for a way to heal their fractured bond and return their family to the way they once were. Meanwhile, Klaus' suspicion piques when he learns that an old vampire friend named Lucien has arrived to New Orleans with a mysterious agenda involving the Mikaelson's remaining sire lines. Elsewhere, Elijah questions whether he can truly forgive his brother for his mounting offenses, while Hayley struggles with being cursed to her wolf form in the bayou. In the French Quarter, Vincent and Cami assist Detective Kinney after a series of gruesome discoveries are made, leading them to believe they may have a serial killer on the loose. Finally, Marcel, who has regained control of the French Quarter once again, tries a new strategy to recruit vampires, while Davina, who is now Regent to the New Orleans witches, makes a decision that will find her and Marcel on opposite sides of an escalating conflict.

After learning that Cami's life is in danger and Aurora may be to blame, Klaus is forced to engage in another one of her devious games and follows a series of clues she's left behind for him. Meanwhile, Elijah, Freya and Hayley take drastic measures against Tristan when they discover he holds a valuable piece of information they need. Elsewhere, Aya gives Marcel an ultimatum that leaves him with a difficult decision to make, while tensions between Hayley and Jackson cause her to reevaluate her involvement in Mikaelson family matters.

When a powerful weapon that could take down the Mikaelsons for good ends up in the wrong hands, Klaus finds himself in a tense standoff with an unlikely foe. Meanwhile, Elijah's attempt to reclaim control of The Strix leads to a violent showdown and the emergence of a potential new leader. Elsewhere, when a new coven of witches tries to influence Davina into helping them locate the elusive weapon, she quickly realizes she may be in over her head.

Following a violent encounter that has left Cami’s life hanging in the balance, Klaus is forced to rely on his family and allies to find a cure as he keeps a watchful eye over Cami at the compound. With time running out, Freya turns to her arsenal of spells, while Vincent and Marcel head to Cami’s apartment to gather a crucial ingredient. Elsewhere, Hayley and Elijah travel to the bayou in hopes of bringing back a potential antidote that could save Cami’s life. Finally, Davina confronts Lucien and learns some heartbreaking information that will change her future with Kol forever.

On the fifth anniversary of Klaus’ defeat, Marcel is king of the city and welcomes the un-sired vampires to New Orleans, only to find they pose an unexpected threat to his rule, leading him to seek counsel from an unlikely source. Meanwhile, as Hayley closes in on the cure that will allow her to revive Elijah and the slumbering Mikaelsons, she faces a final task that will force her to make a ruthless decision.

The Mikaelsons find themselves out of options as they face the all-powerful and un-killable entity known as The Hollow. With the life of Hope at stake, Vincent proposes a final, desperate plan – one that will force Klaus, Elijah, Hayley, Rebekah and Freya to make the greatest sacrifice their family has ever endured. Season Finale.