Construction workers have inadvertantly released Achira, a ghost that can spread disease. The only ones who could stop this ghost are the Ghostbusters, but they have long since disbanded. In fact, only Egon is still in New York City. He is now teaching a college class, but his four students may prove very helpful against this nasty ghost.

Egon builds new and improved ghost busting equipment for the new team. While they search for Achira, Eduardo again sees Kylie, who has been possessed by Achira.