June 1969. As the world counts down to the first moon landing, Joan flirts with danger at the hospital and makes a powerful enemy. Annie returns home after giving up her baby, but realises her old life is gone forever.

As Kings Cross is invaded by soldiers on rest and relaxation leave from the Vietnam War, Joan helps Viv track down her brother. After losing her baby, Annie's life spirals out of control until she is rescued by an unlikely guardian angel.

Joan's world is rocked when she uncovers the truth about Annie's baby. Shirley's affair with Johnny is exposed when her husband returns injured from Vietnam. Annie's singing career takes off when she appears on TV show Bandstand.

Joan fears the worst when Annie kidnaps her baby back from the McNaughton family. Johnny makes a shocking sacrifice and Patricia's dreams for the future are shattered when her boyfriend finally visits Stanton House.

Patricia refuses to sign adoption papers for her unborn baby, with tragic results. Joan gets closer to finding the family of Gail's orphaned baby. Matron's world is rocked when her biological son is released from prison. Martha is swept off her feet by an admirer.

Joan puts the welfare of Jim’s baby ahead of her career. Matron makes a deal with the devil in order to save Stanton House from closure. Annie gets closer to Chris, unaware of his history.

Martha’s reunion with her birth mother turns into a nightmare. Joan and Jim’s relationship is blown apart by a secret from her past. Annie is distraught to learn she is pregnant again.

In the season final, Joan makes a terrible choice to save her husband. Matron fights a desperate battle to keep Stanton House open. McNaughton makes a fateful decision that has a drastic impact on Joan and Jim’s future.

It’s 1970 and the times they are a-changing. Joan is devastated to discover an infection has left her almost certainly infertile while delinquent teen Maggie is determined to discover the identity of her birth mother.

Shirley fights to keep her job as Maggie learns the truth of their relationship, Joan uncovers McNaughton's part in Greg Mathieson's death, and Viv loses her twins all over again.

In Vietnam, Viv finds herself holding her newly orphaned baby nephew. Joan confirms Eva is pregnant as Patty and Jim give in to their lust.

Annie risks losing her unborn child when she is injured at an anti-war protest. Joan's career as a doctor hangs in the balance following her role in Eva's pregnancy. Shirley makes a life-changing decision to help Maggie keep her baby.

As wedding bells chime, new love blossoms as old loves are lost forever, and amidst betrayal and secrecy, Joan must face the hardest decision of her life.