Lupo and Green investigate the shooting death of young white teenager and a 9 year old black girl. The investigation hits a brick wall when both white and black communities refuse to talk - an unfortunate result of formerly black neighbourhoods being bought out by rich whites. The detectives discover that the teenage victim and two of his friends had a basketball taken from them by a black teenager which eventually led to an altercation with deadly consequences and subsequently to surprising culprits.

A novelist's apparent suicide soon changes to a murder investigation with suspects that include a cult and her husband, but Cutter's case may not be closed when jury tampering puts lives at risk.

A deadly drunk-driving car accident brings Detectives Cyrus Lupo and Kevin Bernard to the scene when a suspicious nasal spray is found. After the medical examiner realizes the nasal spray is a powerful anesthetic that could easily disorient its user, the detectives become suspicious of the victim's boss, Zach Marshall

Lupo and Bernard uncover a possible conspiracy to kill off wealthy cancer patients, so their inheritors don't have to pay an estate tax. However, legal roadblocks make the case difficult to prosecute.