Mako is offered a better life away from poverty. To do so she must don a suit and face Ryuko in combat.

Ryuko’s battle against the Elite Four takes to the skies! Meanwhile, more spectators converge on Honnouji Academy. But who is the mysterious girl strolling through town and what secrets does she hold?

Satsuki Kiryuin joins the front line of Osaka to battle Kaneo Takarada, the heir to the Takarada Conglomerate. Using the influence of money, Takarada rallies the locals to fight, but Satsuki is suspicious there is another power behind the city's defense.

The ongoing battle presses towards Honnouji Academy, but Ragyo and the Original Life Fiber stand in the way. Ryuko and Satsuki set off to face them, leaving Nudist Beach's defense to... Mako?! Meanwhile, a crazed Nui continues working feverishly...

The final confrontation is at hand! Will Ragyo and Nui bring on the end of the world, or will Ryuko and the others be able to stop them?