A college co-ed falls from a balcony and once she is in the ER, TC and Paul find that her situation is even more complex. Jordan bonds with a terminal patient who teaches her some important lessons about living. TC's errant sister-in-law Annie returns and hopes to make amends. Meanwhile, Jessica - a pharmaceutical rep with cutting-edge equipment that Scott is so close to getting for the hospital - if her tension with TC doesn't kill the deal.

Shannon and Jordan venture out for some fun at a local wrestling event only to find themselves treating people on site when a fight breaks out amongst the audience. Back at the hospital, Sam attends to a marathon runner who has collapsed from the heat and things start to heat up even more when the air conditioning breaks. Meanwhile, tensions between TC, Jordan, Sam, and Annie start to boil.

The doctors race to save Topher's mom when she comes to the ER with life-threatening symptoms. The team discovers a gravely injured foster mom is harboring a secret. Jordan asks T.C.'s girlfriend for help with a patient.

TC and Paul pull out all the stops when a crane collapses on a worker at a busy construction site. As Paul works tirelessness to save the crush victim, an observer falls into a deadly gravel pit. TC throws himself into the pit and races to save the patient before he's swallowed by the shifting gravel. Back at the ER, Scott is shaken as the teenage boy he paralyzed returns to the hospital with new complications. Jordan lends support as the emotional case exposes complicated feelings from the past. Meanwhile when a life-saving donor matches with cystic fibrosis patient, Brianna, Drew determines the depth of his feelings for her.

TC initiates a bar brawl, landing him and Drew in jail for the night. While behind bars, Drew and TC's relationship reaches a breaking point. Jordan rushes her date to the ER, where she's shocked to learn he's not who she thought he was. Topher fights for a patient who many doctors have dismissed. Scott and Annie struggle to save their relationship while Jessica works to win back TC's trust. Meanwhile, Syd meets Brianna, and Rick visits the hospital.

Scott and Jordan must perform surgery in the field as the burning wildfire gains intensity around them. Syd has caught Typhus along with hundreds of other patients on the Syria-Turkey border, and TC goes to great lengths to get the medication. Meanwhile, Drew and Rick fight to keep Brianna, while San Antonio Memorial finds an unlikely buyer, though saving the hospital comes at a cost.