The hospital readies for its move uptown, while Dr. Edwards makes a play to be named permanent chief of surgery and Dr. Gallinger heads over to Cromartie Hospital in hopes of getting Dr. Thackery to come back to work. Bertie rebuffs Lucy's attempt to make amends. Ping Wu demands his prostitutes be given regular medical checkups. Speight tracks a new plague. Cornelia ministers to a quarantined San Francisco neighborhood.

Thackery attempts a new cure in the inebriation ward; Brockhurst demands his "girls" be returned; Gallinger and his wife's relationship and Bertie's relationship with Genevieve go off in surprising directions. Later, Cornelia shows evidence of the company's wrongdoing to Henry; Barrow's marriage troubles come to a head; and Thackery performs plastic surgery on Abby.