Three years into the zombie apocalypse, a ragtag team of everyday heroes comes together to transport the only known survivor of the zombie virus from Upstate New York to a lab in California, in hopes of using his blood for a vaccine. A zombie baby proves to be an early obstacle, and what they don't know is that their last, best hope for a vaccine is hiding a dark secret that threatens them all.

The survivors struggle to recover from a shocking death; and in Kansas they happen upon a gun show that makes the zombie apocalypse look calm.

While crossing the Mississippi, the team splits up after a boating accident; 10K is drawn into a scam; Escorpion sentences 10K, Sketchy and Skeezy to death.

On the road to find Lucy in Illinois, Doc and Addy are forced off the road by a retro presidential limo. Turns out Sketchy is running for "President of the Apocalypse" with Skeezy as his campaign manager. Doc and Addy follow them to Wall Drug, South Dakota and witness the somehow lucrative, always entertaining train wreck that is Sketchy and Skeezy.

Doc and our heroes are reunited with Sketchy and Skeezy when they take refuge in a working barber shop full of mysterious characters, one of whom Doc knows but can't remember from where.

As Doc explains his version of American history to George, Sketchy and Skeezy reenact Doc's stories about the Founding Fathers; Warren and the others go to the bakery that invented bizkits in search of the secret ingredient.