While preparing to leave on a fishing trip, Martha Roberts, an erratic whistleblower who calls Pride her mentor, kidnaps him to help her locate a serial killer targeting young women in the Gulf of Mexico.

After Pride's assistant escapes from a kidnapper, the team uncovers evidence of a suspect who is harvesting organs from multiple victims; Pride turns to a friend for guidance as he struggles with the ramifications of his recent brush with death.

After Eddie Barrett provides an alibi witness, Pride and the team are more determined than ever to find a break in the case and avenge Lasalle's murder.

When a man impersonating Lasalle attempts to free a young woman from jail, the team investigates both the imposter and the prisoner. Also, Pride's daughter pays him a surprise visit.

When an NOPD officer is murdered, Pride and the NCIS team take on a group of dirty cops when they discover that the victim was also a key witness in multiple excessive force cases. Also, Tammy faces the reality of being in a new relationship.

As the NCIS team continue to investigate the murder of an officer who was about to whistle blow on police misconduct within NOPD, Pride must get creative in order to finally get rid of the dirty cops. Also, the Mayor asks Pride to join her new task force to address systemic issues plaguing their city and, as Covid continues to overwhelm the system, Wade finally addresses the toll it's taken on her.

When a Petty Officer is shot down by a sniper, Pride and NCIS hunt down the killer, only to find that he may not be acting alone. Also, Rita tells Pride that she has been offered a compelling job... in Kansas City.