NCIS investigates a private plane crash after a Navy pilot says she saw an unidentified object prior to the crash. Pride suffers from insomnia and nightmares as a result of being kidnapped and drugged last year.

After Eddie Barrett provides an alibi witness, Pride and the team are more determined than ever to find a break in the case and avenge Lasalle's murder.

Pride is cut off from the team and backed into a corner after the investigation into Eddie Barrett uncovers a malicious plot.

When Pride is unable to sleep due to continuing nightmares about the mysterious man in the red suit, he undergoes a specialized treatment to help him figure out the man’s identity. Also, an arrogant new officer, Special Agent Quentin Carter, joins the team.

As New Orleans grapples with the effects of COVID-19, Pride sends Tammy and Carter to investigate a suspicious death aboard a humanitarian ship offshore, where they learn that some crew members are infected with the deadly disease. Meanwhile, Wade is overwhelmed by the high volume in the morgue due to COVID-19.

As Tammy and Carter continue to investigate the suspicious death aboard a COVID-infected humanitarian ship offshore, Pride and the team discover that the PPE they were sent to distribute may hold the key to finding the killer.

After a Molotov cocktail is hurled into Pride's bar, evidence leads him directing to his old nemesis, Sasha Brousard, who has been keeping a secret that will affect his life forever. Also, Tammy uses her profiling skills on Hannah and Carter with shocking accuracy.