After Jane discovers Mateo’s abduction, chaos ensues, especially when they all learn Sin Rostro is involved and demanding a ransom. Jane must also focus on motherhood and turns to Xo and Alba for help, leaving Rafael feeling left out. Meanwhile, Petra is conflicted with what to do with Rafael’s remaining sperm sample.

When a slot opens up in the graduate program that Jane has been waiting for, she is faced with her first big motherhood dilemma -- leaving Mateo sooner than expected. Rafael is still reeling from Petra's news as he tries to help plan Mateo's baptism with Jane. Xo helps Rogelio confront his past even though it makes Xo uncomfortable. Meanwhile, Michael takes some advice from Rogelio about how to handle Jane, but it is easier said than done for him.

As Jane tries to juggle motherhood and school, she forgets to plan Lina's surprise 25th birthday party leading to friction between the best friends. Rafael tells Jane that he still wants a romantic relationship with her, but she is blindsided when he asks for joint custody. Petra tries to enlist Michael's help to keep Jane and Rafael apart. Rogelio's ex-wife, Luciana, is blackmailing him with secrets from years ago to get her role back on "The Passions of Santos." Meanwhile, Michael gets a new partner and a possible lead in the Sin Rostro case.

Jane thinks she is finally ready to make a decision about her love life. Alba has taken the proper steps to become a citizen, but Xo's past might make it more difficult than anyone was expecting. Rogelio learns that his nemesis, Britney Spears, is at the Marbella Hotel and he is determined to confront her about their past. Michael is so caught up in his ongoing feud with Rafael that he ends up in big trouble at work. Meanwhile, Petra gets an offer from her ex Milos she just can't refuse.

Jane and Rafael begin estate planning for Mateo, but when Jane realizes that Mateo will inherit millions, she worries he will become spoiled. Jane is also finally starting graduate school, but her professor is not sympathetic to her situation. Rogelio's famous show is ending, so he decides to create his own show, with Xo's encouragement. Petra is shocked to learn what she is having and turns to Jane for advice and help in getting her mother out of prison. Meanwhile, after Michael's issues at work, he has decided to go rogue and is even more determined to catch Sin Rostro.

Jane and Rafael interview potential babysitters to help take some of the pressure off everyone, but Jane has specific and lengthy requirements. Jane attends her graduate school's Christmas party in hopes of finding the perfect writing advisor, but things don't go quite as planned. Rogelio is faced with a tough decision about the direction of his life. Petra wants a friendship with Jane, but her mother's antics once again thwart those efforts. Meanwhile, Michael's suspicions have turned out to be true and he thinks he has discovered a lead on a possible rival to Sin Rostro.

Jane's latest parenting obstacle is sleep training Mateo, a struggle that has the Villanueva woman divided on what is the best method. At the same time, she is beginning her new job as a TA and is faced with a class full of basketball players looking for an easy A. Petra confesses all to Rafael and is determined to put her mother away for good. Rogelio's mother Liliana comes for a visit and reveals a 40 year old family secret. Meanwhile, Michael discovers the truth about Luisa's mother and new information about Rafael's mother.

In the middle of the night, Jane gets a burst of creative energy and starts her thesis. Unfortunately, Mateo spills orange juice all over her computer causing it to crash and Jane loses all her hard work. When Jane brings her computer to be fixed, she meets Dax and with the urging of her friend Lina (guest star Diane Guerrero), Jane considers dating again. Rogelio decides to have his mother Liliana become his manager, but soon realizes that was not the best decision. When Rafael comes to after being attacked by his mother now known to be the crime lord Mutter, he goes to Michael.

Jane and Michael are back together – almost! Jane attempts to get Rafael and Michael to reconcile, but it doesn’t go well. While Rafael is sulking over losing Jane, he is ignoring Petra and her pregnancy needs. Xo and Rogelio have broken up over the baby issue, but they are still acting like a couple, something Jane sees as a problem. Rogelio hires a new assistant, Paolo, who appears too good to be true.

Jane and Michael are back together and Jane wishes she had never left Michael in the first place. Rafael appears to have regressed to his playboy ways and Petra is concerned about him. But Petra is not aware that Rafael is helping Michael find Mutter's other son, Derek. Rogelio's new assistant, Paolo, is actually his stalker Lola. Finally, Petra gives birth to the twins.

Rafael and Petra are new parents but Petra is already back to work and appears to be not interested in motherhood. Xo has invited Alba's old flame Pablo to visit. This does not sit well with Alba as she believes Pablo is cursed and will bring bad luck. Jane is growing concerned that she can't get in touch with her father, Rogelio, who is being held captive by Lola.

With Jane and Xo still dealing with the fallout from Jane's bachelorette party, Jane is now left with finding someone to watch Mateo. When Michael volunteers to help everything is perfect until Mateo does something for the first time in front of Rafael, upsetting him. Rogelio gets in trouble with the network executives when he uses the crew for his own use, so he turns to his favorite writer Dina to help fix the problem. Meanwhile, someone is causing problems for Petra at the Marbella and in her personal life. 

The Villanueva women have a tradition for Mother's Day and Jane is excited to get to participate in her first one as a mom. However, their plans are thwarted when Petra invites everyone to a brunch instead. Jane's TA position is put into jeopardy when a mysterious ad appears in the college newspaper. Rogelio is hurt when Dina doesn't invite him to her birthday party, so he asks Jane to help in an unusual way. Rafael finds himself in big trouble thanks to his half-brother. Meanwhile, Xo finds herself in a compromising position.

Jane has made big plans to celebrate Mateo’s first birthday, but things start to fall apart when she learns there might be an issue with her wedding venue. Rogelio faces a challenge on set that could jeopardize Jane’s big day. Jane is excited when Alba gives her a lead on a book publisher, but soon begins having doubts about her writing. Jane and Petra try to help Rafael figure out his troubles, but they have differing opinions on how to handle the situation. Meanwhile, Michael is convinced that Derek is really in cahoots with Mutter and has a plan to prove it.

After moving up the wedding day, Jane and Michael find all their carefully made plans thrown into chaos. To make matters worse, Jane is unhappy with her current graduate thesis, but changing it might put a wrinkle in her big day. Rafael still has feelings for Jane, but is torn about whether he should speak now or forever hold his peace. Petra has her own family drama when Anezka has a medical emergency and ends up in the hospital. Meanwhile, Rogelio and Xo are finally coming to terms with the state of their relationship until Xo gets surprising news.

Jane and Michael’s housewarming party in their new home hits a snag when they discover they are being evicted for not paying their rent. Rogelio is still trying to break into American television, but needs some unusual help from Rafael. Xo makes a new career choice, but Alba and Jane aren’t convinced this is the one for her. Meanwhile, “Petra” shocks Rafael with what she wants to do with her shares of the hotel.

Jane convinces Alba to let her read the letters from her estranged sister, but under the condition Jane doesn’t reach out to her family. Rafael is starting to suspect that something is different with Petra. Meanwhile, Michael and Rafael, with the help of Jane and Rogelio, try to create a civil friendship, but it doesn’t go as smoothly as everyone hoped.

When Jane is offered a book deal, she thinks her prayers have been answered and debates quitting her awful publishing job. After suffering from panic attacks, Jane is ready to get to the root of the problem. Rogelio and Xo are working on fixing their friendship until Xo finds out that Rogelio has been lying to everyone all this time. Petra is running damage control on the Marbella’s reputation after a grisly discovery is found on the property. Meanwhile, Rafael is ready to be involved again in the Mirabella and his first order of business is finding the perfect person to manage the hotel lounge.

Jane feels guilty that she isn’t around for Mateo as much as she would like, so she decides to run for Room Mom against none other than perfect mom, Petra. With the help of Jane and Xo, Alba tries to impress her crush. Rafael tries to be there for both Jane and Petra. Meanwhile, Rogelio tries to slyly get information from Mateo about Xo and Bruce’s relationship.

Jane struggles to find the right words for Rogelio and Xo’s ceremony, when she learns about a mysterious letter that Michael wrote before their wedding. Rogelio and Xo are excited for their big day, but Rogelio gets some shocking news that could put things on hold. Once again Rafael is upset with Luisa and asks her to leave, but Luisa has a plan of her own. Meanwhile, Petra is skeptical about Jane’s feelings for Rafael which leads her to make a rash decision.

When Jane is reunited with her first love, Adam, she is shocked but happy to see him, however Xo and Alba are less thrilled that he is back. After Rafael loses ownership of the hotel to his sister, he finds himself at Jane's house, broke and homeless. Jane and Rafael learn that Petra has been found and they rush to her aide, but Anezka is nowhere to be found. Meanwhile, Xo and Rogelio wedded bliss is interrupted when they confront the realization that Darci is having Rogelio's baby and she wants full custody.

When Jane learns that Rafael introduced Mateo to his new girlfriend, Katherine, without her consent she gets angry since she thinks Katherine has a negative influence on both Rafael and Mateo. Jane turns to Petra for help with the situation with Rafael, but Petra makes Jane an offer she can't refuse. Now that the baby is born, Rogelio and Darci struggle to choose a name for the baby they both agree on. Meanwhile, Xo is focused on growing the dance studio and decides to go into business with an unlikely foe.

Jane's book is finally being released but her plans to have a party at the local bookshop where she was inspired to be a writer hit a snag. Always wanting to help Jane, Rogelio devises a plan to save the day, but one of his archrivals threatens to ruin the day. Rafael finds a job, but it is not exactly what he was hoping for. Meanwhile, Petra has come up with an interesting strategy to get the Marbella back, but Rafael wants nothing to do with it.

When Jane, Rogelio and Alba learn what is going on with Xo, they all try to comfort her, but Xo insists they let her live her life. Rogelio finally gets River Fields to agree to meet with him, but he learns that River has another plan in mind. Rafael is on a mission to find his sister who may have the information he has been looking for. Meanwhile, Jane is upset with Petra after her girls spill a secret to Mateo.

Jane believes she and Rafael are in a good place until she realizes he is keeping a secret from her. Alba's big day has finally arrived, and Jane, Xo and Rogelio are ready to celebrate but Alba has other plans. Petra and JR make a decision about their future that neither of them saw coming. Meanwhile, River spends the week with Rogelio in order to help them be believable as a married couple, but she soon starts to take her role too seriously.