When the Egyptian God of Chaos inhabits a human body, he attempts to release Pure Evil into the world, thus beginning the final battle of Good vs. Evil. In order to stop him, the Librarians must decipher a series of clues within a science museum, including a mysterious warning spoken by exhibit mannequins that have come to life.

The Librarians' two-front battle comes to a head when the Library is simultaneously infiltrated by DOSA and Apep. Flynn, Baird, Stone, Cassandra, Ezekiel and Jenkins must all put aside their differences in an attempt to save the Library, the world and themselves.

When a secret sect of the Vatican Church unearths an ancient map detailing the locations of the four cornerstones of the Library of Alexandria (the original Library), it’s up to Flynn and the Librarians – with the help of an unexpected ally – to stop them before the stones can be used to destroy the Library.

When Baird goes after Nicole Noone in an attempt to repair her rift with the Library, she ends up joining Nicole in a mission to retrieve a dangerous artifact before it falls into the hands of Russian grave robbers. But can she convince Nicole to forgive the Library and return home with her? Or, will Nicole open Baird's eyes to the dangers of a Guardian dedicating herself, heart and soul, to the Library?

When Jenkins body-switches with a 28-year-old slacker named Jeff, he must find his way back into the Library to correct the mistake. But he will need a team to do it, and enlists the help of Jeff’s hapless Dungeons & Dragons friends. Can they make it in time, before Jeff destroys the Library?