Jackson, Jamie and Agent Shaffer search for a chemist in Alabama who has evidence of Reiden Global's role in the growing animal problem. Meanwhile, Chloe, Mitch and Abraham fly to Rio de Janeiro to delay the local government's plan for a massive bat extermination and come up against a ruthless drug lord.

Abraham works to save Chloe and Mitch from a drug lord; Jackson and Jamie continue to work with Agent Shaffer in search of Evan Lee Hartley and the Mother Cell after Leo is killed in the crash.

The team discovers a terrifying rat infestation when a cargo ship carrying the bloodthirsty rodents washes up off the coast of Massachusetts. Also, unbeknownst to the rest of the team, Mitch reconnects with his terminally ill daughter in Boston as he prepares to make a trade with Reiden-Global to save her life.

Jamie contacts a fellow journalist in an attempt to expose the truth about Reiden’s involvement in the global animal problem. After realizing Delavenne works for Reiden, Mitch escapes with both the Mother Cell and his daughter’s medication. However, on their way to deliver the medication, Mitch and Abraham come face-to-face with a terrifying army of birds.

Following a shift in violent animal behavior, the team attempt to rescue Jamie and secure the leopard that could hold the key to curing the animal crisis.

Mitch and Jamie hatch a daring plan to undermine the Noah Objective once and for all, and the team reunites on the Island of Pangaea where the final pieces of the cure are put in place.

Mitch and Jamie hatch a daring plan to undermine the Noah Objective once and for all, and the team reunites on the Island of Pangaea where the final pieces of the cure are put in place.